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Amantadine Generic Name & Formulations
Legal Class
Rx
General Description
Amantadine HCl 100mg; tabs.
Pharmacological Class
Dopamine agonist.
See Also
How Supplied
Contact supplier.
Manufacturer
Amantadine Indications
Indications
Parkinsonism. Drug-induced extrapyramidal reactions.
Amantadine Dosage and Administration
Adult
Parkinsonism monotherapy: initially 100mg twice daily, may increase after 1–2 weeks by 100mg daily. Serious associated illness or high doses of other antiparkinson drugs: 100mg once daily, may increase after 1 to several weeks to 100mg twice daily; max 400mg/day in divided doses. Extrapyramidal disorders: 100mg twice daily; max 300mg/day in divided doses. Renal dysfunction: reduce dose; see literature.
Children
Not recommended.
Amantadine Contraindications
Not Applicable
Amantadine Boxed Warnings
Not Applicable
Amantadine Warnings/Precautions
Warnings/Precautions
Adjust dose gradually. History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Amantadine Pharmacokinetics
See Literature
Amantadine Interactions
Interactions
Caution with CNS stimulants. Thioridazine may worsen tremor in elderly patients with parkinsonism.
Amantadine Adverse Reactions
Adverse Reactions
Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue.
Amantadine Clinical Trials
See Literature
Amantadine Note
Notes
Formerly known under the brand name Symmetrel.
Amantadine Patient Counseling
See Literature
Amantadine Generic Name & Formulations
Legal Class
Rx
General Description
Amantadine HCl 100mg; tabs.
Pharmacological Class
Adamantane.
See Also
How Supplied
Contact supplier.
Manufacturer
Amantadine Indications
Indications
Prophylaxis and treatment of influenza A infections.
Amantadine Dosage and Administration
Adult
200mg daily in 1–2 divided doses. Elderly: 100mg/day. Renal dysfunction: reduce dose; see literature.
Children
<1yr: not recommended. 1–9yrs: 4.4–8.8mg/kg per day; max 150mg daily. 9–12yrs: 100mg twice daily. Renal dysfunction: reduce dose; see literature.
Amantadine Contraindications
Not Applicable
Amantadine Boxed Warnings
Not Applicable
Amantadine Warnings/Precautions
Warnings/Precautions
History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Amantadine Pharmacokinetics
See Literature
Amantadine Interactions
Interactions
Caution with CNS stimulants.
Amantadine Adverse Reactions
Adverse Reactions
Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue.
Amantadine Clinical Trials
See Literature
Amantadine Note
Notes
Formerly known under the brand name Symmetrel.
Amantadine Patient Counseling
See Literature
