Tdvax

Primary Immunization

• <7yrs: not established. ≥7yrs: Give IM in deltoid muscle. 

• Previously unvaccinated: three 0.5mL doses at elected date, then 4–8 weeks after first dose, and 6–12 months after second dose. 

Routine Booster Immunization

• Give booster dose at 11–12yrs of age and every 10yrs thereafter. 

Tetanus Prophylaxis in Wound Management

• For active tetanus immunization in wound management of patients ≥7yrs, use a preparation containing tetanus and diphtheria toxoids instead of a single-antigen tetanus toxoid.

• Tdvax is approved for wound management of patients ≥7yrs. 

• Active immunization with or without Tetanus Immune Globulin (TIG) (Human) is based on both the wound condition and vaccination history. If indicated, administer TIG (Human) at a separate site. 

• Administer only passive immunization with TIG (Human) in individuals with a contraindication to using tetanus toxoid-containing preparations who did not receive primary immunization of tetanus toxioid and have a clean, minor wound.

• Guide for use of Tetanus and Diphtheria Toxoids Adsorbed (Td) for Tetanus Prophylaxis in Routine Wound Management:

• History of Adsorbed Tetanus Toxoid: Unknown or less than 3 doses

• Clean, Minor Wounds (Td): YES; (TIG): NO

• All Other Wounds (Td): YES; (TIG): YES

• History of Adsorbed Tetanus Toxoid: 3 or more doses

• Clean, Minor Wounds (Td): NO (Yes, if ≥10yrs since last dose); (TIG): NO

• All Other Wounds (Td): NO (Yes, if ≥5yrs since last dose); (TIG): NO

Diphtheria Prophylaxis for Case Contacts

• May be used for post-exposure diphtheria prophylaxis in persons ≥7yrs who have not completed primary vaccination, vaccination status is unknown, or who have not been vaccinated with diphtheria toxoid within the previous 5 years.

• Consult ACIP recommendations for additional interventions.