Comirnaty

During storage, minimize exposure to room light, and avoid exposure to direct sunlight and ultraviolet light. Do not refreeze thawed vials or prefilled syringes.

• Storage of Single Dose Vials and Prefilled Syringes Prior to Use:

  • Cartons of single dose vials and prefilled syringes may arrive frozen at ultra-cold conditions in thermal containers with dry ice.

  • When received, frozen vials and prefilled syringes may be immediately transferred to the refrigerator [2ºC to 8ºC (35ºF to 46ºF)], thawed, and stored for up to 10 weeks. Record the 10-week refrigerated expiry date on the carton at the time of transfer. Cartons of 10 single dose vials or cartons of 10 single dose prefilled syringes may take up to 2 hours to thaw at this temperature.

  • Alternatively, frozen vials and prefilled syringes may be stored in an ultra-low temperature freezer at -90ºC to -60ºC (-130ºF to -76ºF). Do not store vials at -25°C to -15°C (-13°F to 5°F). Once thawed, they should not be refrozen.

  • If cartons of Comirnaty single dose vials and prefilled syringes are received at 2ºC to 8ºC (35ºF to 46ºF), they should be stored at 2ºC to 8ºC.

  • Do not use the vaccine after the expiration date printed on the vials, prefilled syringes, and cartons regardless of storage conditions.

• Storage of Single Dose Vials During Use:

  • If not previously thawed at 2ºC to 8ºC (35ºF to 46ºF), allow vials to thaw at room temperature [up to 25ºC (77ºF)] for 30 minutes.

  • Thawed Comirnaty single dose vials may be stored at room temperature [8°C to 25°C (46°F to 77°F)] for a total of 12 hours.
• Thawing and Storage of Prefilled Syringes:

  • Frozen prefilled syringes should be thawed at 2ºC to 8ºC (35ºF to 46ºF), for 2 hours.

  • A full carton of prefilled syringes may also be thawed at room temperature [up to 25ºC (77ºF)] for
    60 minutes.

  • Prefilled syringes thawed in the carton by either method may be stored in the refrigerator for 10 weeks and at room temperature [8°C to 25°C (46°F to 77°F)] for 12 hours prior to use.

  • If individual frozen prefilled syringes are thawed at room temperature outside of the carton, they can be kept at room temperature and must be used within 4 hours of thawing.

  • After removing the tip cap and attaching an appropriate needle, the prefilled syringe should be used immediately. If it cannot be used immediately, it must be used within 4 hours.

• Transportation of Vials and Prefilled Syringes:

  • If local redistribution is needed, single dose vials and prefilled syringes may be transported at -90°C to -60°C (-130°F to -76°F), or at 2°C to 8°C (35°F to 46°F).

  • Prefilled syringes should only be transported at -90°C to -60°C if the cartons are sealed in the original aluminum shipping pouches.