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Kineret Generic Name & Formulations
Legal Class
Rx
General Description
Anakinra 100mg/0.67mL; soln for SC inj; preservative-free.
Pharmacological Class
Interleukin-1 (IL-1) blocker.
How Supplied
Single-dose syringe—7, 28
Manufacturer
Kineret Indications
Indications
To reduce signs/symptoms and slow progression of structural damage in moderately to severely active rheumatoid arthritis (RA) that failed DMARD(s), as monotherapy or with DMARDs other than TNF blockers.
Kineret Dosage and Administration
Adult
≥18yrs: 100mg SC once daily. Severe renal impairment or ESRD (CrCl <30mL/min): may consider every other day dosing.
Children
<18yrs: not recommended.
Kineret Contraindications
Contraindications
Hypersensitivity to E. coli-derived proteins.
Kineret Boxed Warnings
Not Applicable
Kineret Warnings/Precautions
Warnings/Precautions
Increased risk of serious infections; discontinue if develop in RA patients; consider risk vs. benefit in NOMID and DIRA patients. Active infections: do not initiate. Chronic infections (eg, tuberculosis). Asthma. Immunosuppression. Malignancies. Discontinue if severe hypersensitivity reaction occurs. Increased risk of allergic reactions in DIRA patients; monitor closely esp in the first several weeks after initiation; consider discontinuing if severe allergic reaction occurs. Monitor neutrophil count at baseline, monthly for first 3 months, then every 3 months for up to 1 year. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.
Kineret Pharmacokinetics
See Literature
Kineret Interactions
Interactions
Concomitant TNF blockers; not recommended. Avoid concurrent live vaccines.
Kineret Adverse Reactions
Adverse Reactions
Inj site reactions, upper RTI, headache, nausea, diarrhea, sinusitis, arthralgia, flu-like symptoms, abdominal pain, pyrexia, gastroenteritis; infections, neutropenia.
Kineret Clinical Trials
See Literature
Kineret Note
Not Applicable
Kineret Patient Counseling
See Literature
Kineret Generic Name & Formulations
Legal Class
Rx
General Description
Anakinra 100mg/0.67mL; soln for SC inj; preservative-free.
Pharmacological Class
Interleukin-1 (IL-1) blocker.
How Supplied
Single-dose syringe—7, 28
Manufacturer
Kineret Indications
Indications
Neonatal-Onset Multisystem Inflammatory Disease (NOMID). Deficiency of interleukin-1 receptor antagonist (DIRA).
Kineret Dosage and Administration
Adult
≥18yrs: not applicable.
Children
<18yrs: Initially 1–2mg/kg SC daily; may adjust by increments of 0.5–1mg/kg; max 8mg/kg/day. For NOMID: usually give once daily, but dose may be split into twice daily administration. Severe renal impairment or ESRD (CrCl <30mL/min): may consider every other day dosing.
Kineret Contraindications
Contraindications
Hypersensitivity to E. coli-derived proteins.
Kineret Boxed Warnings
Not Applicable
Kineret Warnings/Precautions
Warnings/Precautions
Increased risk of serious infections; discontinue if develop in RA patients; consider risk vs. benefit in NOMID and DIRA patients. Active infections: do not initiate. Chronic infections (eg, tuberculosis). Asthma. Immunosuppression. Malignancies. Discontinue if severe hypersensitivity reaction occurs. Increased risk of allergic reactions in DIRA patients; monitor closely esp in the first several weeks after initiation; consider discontinuing if severe allergic reaction occurs. Monitor neutrophil count at baseline, monthly for first 3 months, then every 3 months for up to 1 year. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.
Kineret Pharmacokinetics
See Literature
Kineret Interactions
Interactions
Concomitant TNF blockers; not recommended. Avoid concurrent live vaccines.
Kineret Adverse Reactions
Adverse Reactions
Inj site reactions, upper RTI, headache, nausea, diarrhea, sinusitis, arthralgia, flu-like symptoms, abdominal pain, pyrexia, gastroenteritis; infections, neutropenia.
Kineret Clinical Trials
See Literature
Kineret Note
Not Applicable
Kineret Patient Counseling
See Literature
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