Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Azasan Generic Name & Formulations
Legal Class
Rx
General Description
Azathioprine 75mg, 100mg; scored tabs.
Pharmacological Class
Immunosuppressant.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Azasan Indications
Indications
To reduce signs/symptoms of active rheumatoid arthritis; may be used with aspirin, NSAIDs, and/or low dose corticosteroids.
Azasan Dosage and Administration
Adult
Initially: 1mg/kg (50mg–100mg) daily in 1–2 divided doses; after 6–8 wks, if needed, may increase by 0.5mg/kg daily increments every 4-weeks. Max: 2.5mg/kg per day. Maintenance: use lowest effective dose.
Children
Not recommended.
Azasan Contraindications
Contraindications
Pregnancy (Cat.D). Prior treatment with alkylating agents (eg, cyclophosphamide, chlorambucil, melphalan, or others) may increase risk of neoplasia.
Azasan Boxed Warnings
Not Applicable
Azasan Warnings/Precautions
Warnings/Precautions
Be fully familiar with product's toxicity before use. Risk of myelotoxicity with low or absent thiopurine S-methyl transferase (TPMT) activity. Monitor blood. Impaired renal function. Discontinue if ineffective after 12 weeks. Nursing mothers: not recommended.
Azasan Pharmacokinetics
See Literature
Azasan Interactions
Interactions
Reduce dose to ⅓ or ¼ with allopurinol. TPMT enzyme inhibition with aminosalicylates (eg, sulphasalazine, mesalazine, olsalazine). Leukopenia with co-trimoxazole. Anemia, leukopenia with ACE Inhibitors. May antagonize warfarin.
Azasan Adverse Reactions
Adverse Reactions
Severe leukopenia and/or thrombocytopenia, macrocytic anemia, pancytopenia, severe bone marrow suppression, GI disturbances, secondary infections, mutagenic and carcinogenic potential, hepatotoxicity, rash.
Azasan Clinical Trials
See Literature
Azasan Note
Not Applicable
Azasan Patient Counseling
See Literature
Azasan Generic Name & Formulations
Legal Class
Rx
General Description
Azathioprine 75mg, 100mg; scored tabs.
Pharmacological Class
Immunosuppressant.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Azasan Indications
Indications
Adjunct for the prevention of rejection in renal homotransplantation.
Azasan Dosage and Administration
Adult
Start at time of transplant or 1–3 days prior; usually with IV formulation. Initially: 3–5 mg/kg daily. Maintenance: 1–3mg/kg daily.
Children
Not recommended.
Azasan Contraindications
Contraindications
Pregnancy (Cat.D).
Azasan Boxed Warnings
Not Applicable
Azasan Warnings/Precautions
Warnings/Precautions
Be fully familiar with product's toxicity before use; consider discontinuing if severe toxicity occurs. Risk of myelotoxicity with low or absent thiopurine S-methyl transferase (TPMT) activity. Monitor blood. Impaired renal function. Nursing mothers: not recommended.
Azasan Pharmacokinetics
See Literature
Azasan Interactions
Interactions
Reduce dose to ⅓ or ¼ with allopurinol. TPMT enzyme inhibition with aminosalicylates (eg, sulphasalazine, mesalazine, olsalazine). Leukopenia with co-trimoxazole. Anemia, leukopenia with ACE Inhibitors. May antagonize warfarin.
Azasan Adverse Reactions
Adverse Reactions
Severe leukopenia and/or thrombocytopenia, macrocytic anemia, pancytopenia, severe bone marrow suppression, GI disturbances, secondary infections, mutagenic and carcinogenic potential, hepatotoxicity, rash.
Azasan Clinical Trials
See Literature
Azasan Note
Not Applicable
Azasan Patient Counseling
See Literature
