Wilate

Give by IV injection at 2–4mL/min. VWD (<5yrs): contact manufacturer; (≥5yrs): Minor bleed: 20–40 IU/kg once, then 20–30 IU/kg every 12–24 hours as needed. Major bleed: 40–60 IU/kg once, then 20–40 IU/kg every 12–24 hours as needed. Surgery (give loading dose within 3hrs before); Minor: 30–60 IU/kg once, then 15–30 IU/kg (or half the loading dose) every 12–24 hours; Major: 40–60 IU/kg once, then 20–40 IU/kg (or half the loading dose) every 12–24 hours. Routine prophylaxis (≥6yrs): 20–40 IU/kg two or three times per week. Monitor and adjust according to VWF:RCo and FVIII activity, and location of bleed; usual treatment duration is 3 days (minor hemorrhage, minor surgery), 5–7 days (major hemorrhage), or ≥6 days (major surgery). Hemophilia A (<12yrs): contact manufacturer; (≥12yrs): Minor bleed: 30–40 IU/kg every 12–24 hours for ≥1 day. Moderate bleed: 30–40 IU/kg every 12–24 hours for ≥3–4 days. Major bleed: 35–50 IU/kg every 12–24 hours for ≥3–4 days. Life-threatening: 35–50 IU/kg every 8–24 hours until resolved. Routine prophylaxis: 20–40 IU/kg every 2–3 days. Monitor and adjust according to severity of deficiency/hemorrhage, desired FVIII level, presence of inhibitor. See full labeling.