Sylvant

Concurrent active severe infections: avoid siltuximab until resolved. May mask signs/symptoms of acute inflammation, fever, and acute phase reactants (eg, CRP); monitor closely. Have resuscitative equipment and personnel available. Discontinue if signs of anaphylaxis occur. Stop infusion if mild-to-moderate infusion reactions occur; if resolves, may restart at lower infusion rate and consider using antihistamines, acetaminophen, corticosteroids. Increased risk for GI perforation. Perform blood tests prior to each dose for the first 12 months and every 3 dosing cycles thereafter. Consider delaying treatment if hematology criteria not met (see full labeling). Advise females of reproductive potential to use effective contraception during and for 3 months after the last dose. Pregnancy. Nursing mothers: not recommended (during and for 3 months after the last dose).