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Pentoxifylline Generic Name & Formulations
Legal Class
Rx
General Description
Pentoxifylline 400mg; ext-rel tabs.
Pharmacological Class
Hemorrheologic agent (xanthine).
How Supplied
Contact supplier
Manufacturer
Pentoxifylline Indications
Indications
Intermittent claudication.
Pentoxifylline Dosage and Administration
Adult
400mg three times daily with meals. Continue for at least 8 weeks. Digestive or CNS effects: lower dosage to 400mg twice daily; discontinue if side effects persist. Severe renal impairment (CrCl <30mL/min): 400mg once daily.
Children
Not established.
Pentoxifylline Contraindications
Contraindications
Recent cerebral or retinal hemorrhage. Methylxanthines intolerance (eg, caffeine, theophylline, theobromine).
Pentoxifylline Boxed Warnings
Not Applicable
Pentoxifylline Warnings/Precautions
Warnings/Precautions
Discontinue if anaphylactic/anaphylactoid reaction occurs. Monitor for bleeding including hematocrit, hemoglobin in patients with hemorrhagic risk factors (eg, recent surgery, peptic ulcer, cerebral and/or retinal bleeding). Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Pentoxifylline Pharmacokinetics
See Literature
Pentoxifylline Interactions
Interactions
See Contraindications. May potentiate antihypertensives; monitor BP. Concomitant theophylline-containing drugs; monitor closely and adjust dose. Bleeding with concomitant NSAIDs, anticoagulants, or platelet aggregation inhibitors. Concomitant warfarin; monitor PT frequently. May be potentiated by strong CYP1A2 inhibitors (eg, ciprofloxacin, fluvoxamine), cimetidine.
Pentoxifylline Adverse Reactions
Adverse Reactions
GI upset, nausea, dyspepsia, flushing, agitation, headache, dizziness, insomnia, blurred vision.
Pentoxifylline Clinical Trials
See Literature
Pentoxifylline Note
Notes
Formerly known under the brand name Trental.
Pentoxifylline Patient Counseling
See Literature
