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Lupron Depot 3.75mg Generic Name & Formulations
Legal Class
Rx
General Description
Leuprolide acetate 3.75mg; depot susp for IM inj; preservative-free.
Pharmacological Class
GnRH analogue.
See Also
How Supplied
Kit—1 (prefilled dual-chamber syringe w. supplies)
Manufacturer
Lupron Depot 3.75mg Indications
Indications
Preoperative improvement of patients with anemia due to uterine leiomyomata (fibroids), with iron therapy if iron therapy alone is inadequate.
Lupron Depot 3.75mg Dosage and Administration
Adult
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 3 months.
Children
<18yrs: not applicable.
Lupron Depot 3.75mg Contraindications
Contraindications
Undiagnosed abnormal vaginal bleeding. Pregnancy. Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Lupron Depot 3.75mg Boxed Warnings
Not Applicable
Lupron Depot 3.75mg Warnings/Precautions
Warnings/Precautions
Exclude pregnancy prior to initiation; advise to use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, family history of osteoporosis, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. History of depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
Lupron Depot 3.75mg Pharmacokinetics
See Literature
Lupron Depot 3.75mg Interactions
Not Applicable
Lupron Depot 3.75mg Adverse Reactions
Adverse Reactions
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain/loss, vaginitis, amenorrhea, acne, skin reactions; bone density loss, convulsions, hypersensitivity reactions; rare: anaphylaxis, asthma.
Lupron Depot 3.75mg Clinical Trials
See Literature
Lupron Depot 3.75mg Note
Not Applicable
Lupron Depot 3.75mg Patient Counseling
See Literature
Lupron Depot 3.75mg Generic Name & Formulations
Legal Class
Rx
General Description
Leuprolide acetate 3.75mg; depot susp for IM inj; preservative-free.
Pharmacological Class
GnRH analogue.
See Also
How Supplied
Kit—1 (prefilled dual-chamber syringe w. supplies)
Manufacturer
Lupron Depot 3.75mg Indications
Indications
Endometriosis management, including pain relief and reduction of endometriotic lesions. With norethindrone acetate: for initial management and recurrent symptoms.
Lupron Depot 3.75mg Dosage and Administration
Adult
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 6 months. May repeat one 6-month cycle; give with norethindrone acetate 5mg daily when retreating (do not use leuprolide alone for retreatment). Max total treatment: 12 months.
Children
<18yrs: not applicable.
Lupron Depot 3.75mg Contraindications
Contraindications
Undiagnosed abnormal vaginal bleeding. Pregnancy. Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Lupron Depot 3.75mg Boxed Warnings
Not Applicable
Lupron Depot 3.75mg Warnings/Precautions
Warnings/Precautions
Exclude pregnancy prior to initiation; advise to use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, family history of osteoporosis, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. History of depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
Lupron Depot 3.75mg Pharmacokinetics
See Literature
Lupron Depot 3.75mg Interactions
Not Applicable
Lupron Depot 3.75mg Adverse Reactions
Adverse Reactions
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain/loss, vaginitis, amenorrhea, acne, skin reactions; bone density loss, convulsions, hypersensitivity reactions; rare: anaphylaxis, asthma.
Lupron Depot 3.75mg Clinical Trials
See Literature
Lupron Depot 3.75mg Note
Not Applicable
Lupron Depot 3.75mg Patient Counseling
See Literature
Lupron Depot 3.75mg Generic Name & Formulations
Legal Class
Rx
General Description
Leuprolide acetate 3.75mg; depot susp for IM inj; preservative-free.
Pharmacological Class
GnRH analogue.
See Also
How Supplied
Kit—1 (prefilled dual-chamber syringe w. supplies)
Manufacturer
Lupron Depot 3.75mg Indications
Indications
Preoperative improvement of patients with anemia due to uterine leiomyomata (fibroids), with iron therapy if iron therapy alone is inadequate.
Lupron Depot 3.75mg Dosage and Administration
Adult
Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. ≥18yrs: 3.75mg once a month for up to 3 months.
Children
<18yrs: not applicable.
Lupron Depot 3.75mg Contraindications
Contraindications
Undiagnosed abnormal vaginal bleeding. Pregnancy. Nursing mothers. When coadministered with norethindrone acetate, its contraindications also apply to this combination regimen.
Lupron Depot 3.75mg Boxed Warnings
Not Applicable
Lupron Depot 3.75mg Warnings/Precautions
Warnings/Precautions
Exclude pregnancy prior to initiation; advise to use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, family history of osteoporosis, anticonvulsants, corticosteroids); consider concomitant norethindrone acetate and supplemental calcium in endometriosis; assess BMD before retreatment. History of depression. Missing successive doses may cause breakthrough bleeding or ovulation. Elderly.
Lupron Depot 3.75mg Pharmacokinetics
See Literature
Lupron Depot 3.75mg Interactions
Not Applicable
Lupron Depot 3.75mg Adverse Reactions
Adverse Reactions
Hot flashes/sweats, headache, decreased libido, depression/emotional lability, dizziness, nausea/vomiting, pain, weight gain/loss, vaginitis, amenorrhea, acne, skin reactions; bone density loss, convulsions, hypersensitivity reactions; rare: anaphylaxis, asthma.
Lupron Depot 3.75mg Clinical Trials
See Literature
Lupron Depot 3.75mg Note
Not Applicable
Lupron Depot 3.75mg Patient Counseling
See Literature
