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Leucovorin Generic Name & Formulations
Legal Class
Rx
General Description
Leucovorin calcium 100mg/vial, 350mg/vial; lyophilized pwd for IV or IM inj after reconstitution; preservative-free.
Pharmacological Class
Folic acid derivative.
How Supplied
Single-use vials—1
Manufacturer
Leucovorin Indications
Indications
Megalobastic anemia due to folic acid deficiency when oral therapy is not feasible.
Leucovorin Dosage and Administration
Adult
Up to 1mg daily.
Children
See literature.
Leucovorin Contraindications
Contraindications
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Boxed Warnings
Not Applicable
Leucovorin Warnings/Precautions
Warnings/Precautions
Do not administer intrathecally. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Pharmacokinetics
See Literature
Leucovorin Interactions
Interactions
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Leucovorin Adverse Reactions
Adverse Reactions
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
Leucovorin Clinical Trials
See Literature
Leucovorin Note
Not Applicable
Leucovorin Patient Counseling
See Literature
Leucovorin Generic Name & Formulations
Legal Class
Rx
General Description
Leucovorin calcium 100mg/vial, 350mg/vial; lyophilized pwd for IV or IM inj after reconstitution; preservative-free.
Pharmacological Class
Folic acid derivative.
How Supplied
Single-use vials—1
Manufacturer
Leucovorin Indications
Indications
Palliative treatment of advanced colorectal cancer in combination with 5-fluorouracil.
Leucovorin Dosage and Administration
Adult
Max IV infusion rate: 160mg/min. 200mg/m2 by slow IV inj over a minimum of 3 minutes, followed by 5-fluorouracil (370mg/m2); or 20mg/m2 IV followed by 5-fluorouracil (425mg/m2); both regimens: daily for 5 days, may be repeated at 4-week intervals for 2 courses and then repeated at 4–5 week intervals (if completely recovered from toxic effects of previous course).
Children
See literature.
Leucovorin Contraindications
Contraindications
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Boxed Warnings
Not Applicable
Leucovorin Warnings/Precautions
Warnings/Precautions
Do not administer intrathecally. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Pharmacokinetics
See Literature
Leucovorin Interactions
Interactions
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Leucovorin Adverse Reactions
Adverse Reactions
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
Leucovorin Clinical Trials
See Literature
Leucovorin Note
Not Applicable
Leucovorin Patient Counseling
See Literature
Leucovorin Generic Name & Formulations
Legal Class
Rx
General Description
Leucovorin calcium 100mg/vial, 350mg/vial; lyophilized pwd for IV or IM inj after reconstitution; preservative-free.
Pharmacological Class
Folic acid derivative.
How Supplied
Single-use vials—1
Manufacturer
Leucovorin Indications
Indications
Rescue treatment after high-dose methotrexate therapy in osteosarcoma.
Leucovorin Dosage and Administration
Adult
Max IV infusion rate: 160mg/min. Based on methotrexate dose. Normal methotrexate elimination: 15mg IM or IV every 6 hours for 10 doses starting 24 hours after the beginning of the methotrexate infusion. Delayed late or delayed early methotrexate elimination, and/or evidence of acute renal injury, impaired methotrexate elimination or inadvertent overdosage: see literature.
Children
See literature.
Leucovorin Contraindications
Contraindications
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Boxed Warnings
Not Applicable
Leucovorin Warnings/Precautions
Warnings/Precautions
Do not administer intrathecally. Monitor serum methotrexate concentration. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Pharmacokinetics
See Literature
Leucovorin Interactions
Interactions
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Leucovorin Adverse Reactions
Adverse Reactions
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
Leucovorin Clinical Trials
See Literature
Leucovorin Note
Not Applicable
Leucovorin Patient Counseling
See Literature
