Gamunex-c

Give by IV infusion at a rate of 1mg/kg/min for first 30mins; if tolerated, may increase to max 8mg/kg/min. 1g/kg once daily given on 2 consecutive days or 0.4g/kg once daily given on 5 consecutive days. If adequate response after first 1g/kg dose, may withhold second dose. Risk of renal dysfunction or thrombosis: give at minimum infusion rate practicable (<8mg/kg/min). Expanded fluid volumes: high dose regimen not recommended.

<2yrs: not established. Individualize. ≥2yrs: IV infusion: 300–600mg/kg IV every 3–4 weeks. Initial infusion rate: 1mg/kg/min for first 30mins; if tolerated, may increase gradually to max 8mg/kg/min. Risk of renal dysfunction or thrombosis: give at minimum infusion rate practicable (<8mg/kg/min). SC infusion: start 1 week after last IGIV infusion. Give by using an infusion pump into abdomen, thigh, upper arm, and/or lateral hip areas. May use up to 6 (children) or 8 (adults) infusion sites (at least 2 inches apart) simultaneously. Obtain serum IgG trough level to guide subsequent dose adjustments. Initial weekly dose = (1.37 x previous IGIV dose [in grams])/number of weeks between IGIV doses. To convert dose to mL, multiply calculated SC dose (in grams) by 10. Infusion rate: adults: 20mL/hr/site; children/adolescents (if <25kg): 10mL/hr/site; (if ≥25kg): initially 15mL/hr/site, then increase up to 20mL/hr/site. Dose adjustments, measles exposure: see full labeling.