Fragmin

Give by deep SC inj; rotate inj sites. Angina, MI: 120 IU/kg (max 10000 IU) every 12hrs until stabilized (usually 5–8 days), with aspirin 75–165mg once daily. Hip replacement, post-op start: 2500 IU 4–8hrs after surgery, then 5000 IU once daily (at least 6 hrs after 1^st dose); hip replacement, pre-op start day of surgery: 2500 IU within 2hrs before surgery, then 2500 IU 4–8hrs after surgery, then 5000 IU once daily (at least 6hrs after previous dose); hip replacement pre-op evening before surgery: 5000 IU 10–14hrs before surgery, then 5000 IU 4–8hrs after surgery, then 5000 IU once daily (allow 24hrs between doses); for all hip replacement regimens: usually treat for 5–10 days; max up to 14 days post-op. Abdominal surgery: 2500 IU once daily (usually for 5–10 days) starting 1–2hrs pre-op; for high risk of thromboembolism (eg, malignancy): see full labeling. Severely restricted mobility: 5000 IU once daily (usually for 12–14 days). Extended treatment of VTE in cancer patients: 200 IU/kg once daily for the first 30 days, then 150 IU/kg once daily for months 2–6; max daily dose 18000 IU; dose reductions for thrombocytopenia or renal insufficiency: see full labeling.