Fibryga

See full labeling. Give by slow IV inj at rate not exceeding 5mL/min. Individualize. Target fibrinogen plasma level: 100mg/dL (minor bleeding); 150mg/dL (major bleeding). Calculate dose when baseline fibrinogen level is known (0–<12yrs): Dose (mg/kg body wt) = [Target level (mg/dL) – measured level (mg/dL)] / 1.4 (mg/dL per mg/kg body wt); (≥12yrs): Dose (mg/kg body wt) = [Target level (mg/dL) – measured level (mg/dL)] / 1.8 (mg/dL per mg/kg body wt). When baseline fibrinogen level is not known: 70mg/kg. Monitor fibrinogen level during therapy. Give additional infusions if fibrinogen level is below the accepted lower limit (80mg/dL [minor bleeding]; 130mg/dL [major bleeding]) until hemostasis is achieved.