Esperoct

Individualize. Infuse slowly over 2mins. <12yrs: Bleeding: 65 IU/kg once; (Minor): one dose is sufficient; (Moderate): an additional dose may be given after 24hrs; (Major): additional dose(s) may be given every 24hrs. Perioperative: 65 IU/kg once; (Minor): additional dose(s) can be given after 24hrs; (Major): additional dose(s) can be given approx. every 24hrs for the first week, then approx. every 48hrs until wound has healed. Routine prophylaxis: 65 IU/kg twice weekly; then may adjust individually based on bleeding episodes. ≥12yrs: Bleeding (Minor): 40 IU/kg once; (Moderate): 40 IU/kg once; an additional dose may be given after 24hrs; (Major): 50 IU/kg once; additional dose(s) may be given every 24hrs. Perioperative: 50 IU/kg once; (Minor): additional dose(s) can be given after 24hrs; (Major): additional dose(s) can be given approx. every 24hrs for the first week, then approx. every 48hrs until wound has healed. Routine prophylaxis: initially 50 IU/kg every 4 days; then may adjust individually based on bleeding episodes. Also to achieve a specific target Factor VIII activity level, calculate dose using: Dosage Required (IU) = Body Weight (kg) × Desired Factor VIII Increase (IU/dL or % of Normal) × 0.5.