Darzalex Faspro

Pre-medicate with corticosteroids (long- or intermediate-acting), acetaminophen, oral or IV antihistamines 1–3 hours prior to every inj and administer oral corticosteroids post inj. Give by SC inj into abdomen over approx. 3–5mins; rotate inj sites. In combination with lenalidomide and dexamethasone (4-week cycle), in combination with pomalidomide and dexamethasone (4-week cycle), or as monotherapy: 1800mg/30000units weekly at Weeks 1–8 (8 doses), every 2 weeks at Weeks 9–24 (8 doses), then every 4 weeks at Week 25 onwards until disease progression. In combination with bortezomib, melphalan and prednisone (6-week cycle): 1800mg/30000units weekly at Weeks 1–6 (6 doses), every three weeks at Weeks 7–54 (16 doses), then every four weeks at Week 55 onwards until disease progression. In combination with bortezomib, thalidomide, and dexamethasone (4-week cycle): 1800mg/30000units weekly at Weeks 1–8 (8 doses), every 2 weeks at Weeks 9–16 (4 doses), stop for high dose chemotherapy and ASCT, then re-initiate every 2 weeks at Weeks 1–8 (4 doses). In combination with bortezomib and dexamethasone (3-week cycle): 1800mg/30000units weekly at Weeks 1–9 (9 doses), every three weeks at Weeks 10–24 (5 doses), then every four weeks at Week 25 onwards until disease progression. Pre- and post-injection medications, others: see full labeling. Prophylaxis for herpes zoster reactivation: initiate antiviral prophylaxis within 1 week after starting therapy and continue for 3 months after treatment.

Pre-medicate with corticosteroids (long- or intermediate-acting), acetaminophen, oral or IV antihistamines 1–3 hours prior to every inj and administer oral corticosteroids post inj. Give by SC inj into abdomen over approx. 3–5mins; rotate inj sites. In combination with bortezomib, cyclophosphamide, and dexamethasone (4-week cycle): 1800mg/30000units weekly at Weeks 1–8 (8 doses), every 2 weeks at Weeks 9–24 (8 doses), then every 4 weeks at Week 25 onwards until disease progression or a max of 2yrs. Pre- and post-injection medications, others: see full labeling. Prophylaxis for herpes zoster reactivation: initiate antiviral prophylaxis within 1 week after starting therapy and continue for 3 months after treatment.