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Cilostazol Generic Name & Formulations
Legal Class
Rx
General Description
Cilostazol 50mg, 100mg; tabs.
Pharmacological Class
Phosphodiesterase 3 (PDE3) inhibitor.
How Supplied
Tabs—60
Manufacturer
Cilostazol Indications
Indications
Intermittent claudication.
Cilostazol Dosage and Administration
Adult
100mg twice daily, ½ hr before or 2 hrs after breakfast and dinner. May reduce to 50mg twice daily if used with CYP3A4 or CYP2C19 inhibitors.
Children
Not established.
Cilostazol Contraindications
Contraindications
Heart failure of any severity.
Cilostazol Boxed Warnings
Boxed Warning
Contraindicated in heart failure patients.
Cilostazol Warnings/Precautions
Warnings/Precautions
Risk of tachycardia, palpitation, tachyarrhythmia, or hypotension. Risk of exacerbations of angina pectoris or MI in patients with history of ischemic heart disease. LV outflow tract obstruction: monitor for development of a new systolic murmur or cardiac symptoms. Monitor platelets and WBC periodically. Avoid use in hemostatic disorders or active pathologic bleeding. Moderate-to-severe hepatic impairment. Severe renal impairment. Dialysis. Pregnancy (Cat.C). Nursing mothers: not recommended.
Cilostazol Pharmacokinetics
See Literature
Cilostazol Interactions
Interactions
Potentiated by drugs that inhibit CYP3A4 (eg, azole antifungals, macrolides, diltiazem, protease inhibitors) or CYP2C19 (eg, omeprazole, fluconazole, fluoxetine, ticlopidine). Avoid grapefruit juice. Cilostazol has been used with aspirin; caution with other antiplatelets, anticoagulants.
Cilostazol Adverse Reactions
Adverse Reactions
Headache, diarrhea, abnormal stools, palpitations, peripheral edema, dizziness, pharyngitis, infection, tachycardia; rare: thrombocytopenia, leukopenia.
Cilostazol Clinical Trials
See Literature
Cilostazol Note
Not Applicable
Cilostazol Patient Counseling
See Literature
