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Argatroban Generic Name & Formulations
Legal Class
Rx
General Description
Argatroban 250mg/2.5mL; soln for IV infusion after dilution.
Pharmacological Class
Direct thrombin inhibitor.
How Supplied
Single-use vial—1
Manufacturer
Generic Availability
YES
Argatroban Indications
Indications
Prophylaxis and treatment of thrombosis in adults with heparin-induced thrombocytopenia (HIT). Anticoagulation in adults with or at risk of HIT undergoing percutaneous coronary intervention (PCI).
Argatroban Dosage and Administration
Adult
Give by IV infusion. HIT: discontinue heparin and obtain baseline aPTT. Initially 2mcg/kg/min; check aPTT 2hrs after starting; titrate to 1.5–3x baseline aPTT (max 100secs); max 10mcg/kg/min. PCI: give 350mcg/kg bolus by large bore IV line over 3–5mins, then initiate infusion of 25mcg/kg/min. Check ACT 5–10mins after bolus; titrate based on activated clotting time (ACT) to therapeutic ACT of 300–450secs (see full labeling). Hepatic impairment: reduce dose and titrate carefully; see full labeling. Conversion to oral anticoagulants: see full labeling.
Children
Not established.
Argatroban Contraindications
Contraindications
Major bleeding.
Argatroban Boxed Warnings
Not Applicable
Argatroban Warnings/Precautions
Warnings/Precautions
Increased bleeding risk (eg, severe hypertension, recent lumbar puncture, spinal anesthesia, major surgery, bleeding disorders, GI lesions). Hepatic impairment. PCI: avoid high doses in significant hepatic disease or AST/ALT ≥3x ULN. Labor & delivery. Pregnancy. Nursing mothers.
Argatroban Pharmacokinetics
See Literature
Argatroban Interactions
Interactions
Increased risk of bleeding with concomitant thrombolytics, warfarin, heparin, antiplatelets, GP IIb/IIIa blockers.
Argatroban Adverse Reactions
Adverse Reactions
Bleeding, dyspnea, hypotension, fever, diarrhea, sepsis, cardiac arrest, chest pain, back pain, nausea, vomiting, headache.
Argatroban Clinical Trials
See Literature
Argatroban Note
Not Applicable
Argatroban Patient Counseling
See Literature
