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Aminocaproic Acid Injection Generic Name & Formulations
Legal Class
Rx
General Description
Aminocaproic acid 250mg/mL; soln for IV infusion after dilution; contains benzyl alcohol.
Pharmacological Class
Hemostatic.
How Supplied
Contact supplier
Manufacturer
Aminocaproic Acid Injection Indications
Indications
Bleeding associated with fibrinolysis.
Aminocaproic Acid Injection Dosage and Administration
Adult
4–5g (in 250mL of diluent) by IV infusion during the 1st hour, then 1g/hour (in 50mL of diluent) for 8 hours or until bleeding is controlled.
Children
Not recommended.
Aminocaproic Acid Injection Contraindications
Contraindications
Active intravascular clotting process. Disseminated intravascular coagulation without concomitant heparin.
Aminocaproic Acid Injection Boxed Warnings
Not Applicable
Aminocaproic Acid Injection Warnings/Precautions
Warnings/Precautions
Upper urinary tract bleeding: not recommended. Cardiac, hepatic or renal disease. Risk of myopathy with long-term use; monitor creatine phosphokinase (CPK); discontinue if CPK rises. Avoid rapid IV administration. Neonates. Pregnancy (Cat.C). Nursing mothers.
Aminocaproic Acid Injection Pharmacokinetics
See Literature
Aminocaproic Acid Injection Interactions
Interactions
Avoid concomitant Factor IX complex or Anti-inhibitor Coagulant concentrates; may increase thrombosis risk.
Aminocaproic Acid Injection Adverse Reactions
Adverse Reactions
Inj site reactions, bradycardia, hypotension, GI upset, edema, headache, malaise, CNS effects, thrombosis, others; rare: myopathy.
Aminocaproic Acid Injection Clinical Trials
See Literature
Aminocaproic Acid Injection Note
Notes
Formerly known under the brand name Amicar.
Aminocaproic Acid Injection Patient Counseling
See Literature
