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Agrylin Generic Name & Formulations
Legal Class
Rx
General Description
Anagrelide (as HCl) 0.5mg; caps.
Pharmacological Class
Platelet-reducing agent (PDE3 inhibitor).
How Supplied
Caps—100
Manufacturer
Generic Availability
YES
Agrylin Indications
Indications
Treatment of thrombocythemia, secondary to myeloproliferative neoplasms, to reduce elevated platelet count and the risk of thrombosis and to improve symptoms.
Agrylin Dosage and Administration
Adult
≥16yrs: Initially 0.5mg four times daily or 1mg twice daily for ≥1 week. May increase dose by 0.5mg/day weekly to maintain normal platelet count; max 10mg/day or 2.5mg/dose. Moderate hepatic impairment: initially 0.5mg/daily.
Children
<7yrs: not established. 7–16yrs: Initially 0.5mg daily. May increase dose by 0.5mg/day weekly to maintain normal platelet count; max 10mg/day or 2.5mg/dose.
Agrylin Contraindications
Not Applicable
Agrylin Boxed Warnings
Not Applicable
Agrylin Warnings/Precautions
Warnings/Precautions
Congenital long QT syndrome, acquired QTc prolongation, hypokalemia: not recommended. Obtain baseline cardiovascular exam and monitor during treatment. Monitor for QTc prolongation and other cardiovascular events in those with hepatic impairment. Heart failure, bradyarrhythmias, electrolyte abnormalities; consider periodic ECG monitoring. Evaluate for underlying cardiopulmonary disease prior to initiation and during therapy. Discontinue and evaluate if pulmonary toxicity is suspected. Monitor CBCs, electrolytes, renal and liver function before initiating and during therapy. Obtain platelet counts every 2 days during 1st week of treatment, then weekly until maintenance dose reached. Cessation may cause platelet count to rise within 4 days. Severe hepatic impairment: avoid. Pregnancy. Nursing mothers: not recommended (during and for 1 week after the last dose).
Agrylin Pharmacokinetics
See Literature
Agrylin Interactions
Interactions
Avoid concomitant drugs that can prolong the QT interval (eg, chloroquine, clarithromycin, haloperidol, methadone, moxifloxacin, amiodarone, disopyramide, procainamide, pimozide), inotropes, other PDE3 inhibitors (eg, cilostazol, milrinone). Concomitant anticoagulants, PDE3 inhibitors, NSAIDs, antiplatelet agents, SSRIs; monitor for bleeding. Potentiated by fluvoxamine, ciprofloxacin or other CYP1A2 inhibitors. Antagonized by omeprazole or other CYP1A2 inducers; may need to adjust dose. May affect CYP1A2 substrates (eg, theophylline, fluvoxamine, ondansetron).
Agrylin Adverse Reactions
Adverse Reactions
Headache, palpitations, diarrhea, asthenia, edema, nausea, abdominal pain, dizziness, pain, dyspnea, flatulence, vomiting, fever, peripheral edema, rash, chest pain, anorexia, tachycardia, malaise, cough, paresthesia, back pain, pruritus, dyspepsia; cardiovascular effects (eg, torsades de pointes, ventricular tachycardia, CHF), pulmonary hypertension, interstitial lung disease.
Agrylin Clinical Trials
See Literature
Agrylin Note
Not Applicable
Agrylin Patient Counseling
See Literature
