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Adakveo Generic Name & Formulations
Legal Class
Rx
General Description
Crizanlizumab-tmca 10mg/mL; per vial; soln for IV infusion after dilution; preservative-free.
Pharmacological Class
Selectin blocker.
How Supplied
Single-dose vial (10mL)—1
Manufacturer
Generic Availability
NO
Adakveo Indications
Indications
To reduce the frequency of vaso-occlusive crises (VOCs) in sickle cell disease.
Adakveo Dosage and Administration
Adult
Give by IV infusion over 30mins. ≥16yrs: 5mg/kg at Week 0, Week 2, and every 4 weeks thereafter.
Children
<16yrs: not established.
Adakveo Contraindications
Not Applicable
Adakveo Boxed Warnings
Not Applicable
Adakveo Warnings/Precautions
Warnings/Precautions
Monitor for infusion-related reactions. Discontinue if severe infusion-related reactions occur; treat appropriately. Interrupt or slow infusion rate if mild to moderate infusion-related reactions occur; treat symptomatically. Consider premedication and/or reduced infusion rate for subsequent infusions. Pregnancy. Nursing mothers.
Adakveo Pharmacokinetics
See Literature
Adakveo Interactions
Interactions
Caution with corticosteroids, unless indicated (eg, treating anaphylaxis). Interferes with automated platelet counts (esp. when collected in tubes containing EDTA) that may lead to unevaluable or falsely decreased platelet counts; run tests within 4hrs of collection or collect in citrate tubes instead.
Adakveo Adverse Reactions
Adverse Reactions
Nausea, arthralgia, back pain, abdominal pain, pyrexia; infusion-related reactions.
Adakveo Clinical Trials
See Literature
Adakveo Note
Not Applicable
Adakveo Patient Counseling
See Literature
