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Zantac Injection Premixed Generic Name & Formulations
Legal Class
Rx
General Description
Ranitidine (as HCl) 1mg/mL in sodium chloride 0.45%; IV infusion; preservative-free.
Pharmacological Class
H2 blocker.
How Supplied
Tabs, syrup—contact supplier; Inj single dose (2mL)—10; Multidose (6mL)—1; Premixed (50mL)—24
Manufacturer
Zantac Injection Premixed Indications
Indications
Hospitalized patients with pathological hypersecretory conditions, intractable duodenal ulcer. Short-term alternative to oral therapy.
Zantac Injection Premixed Dosage and Administration
Adult
For slow IV drip only. >16yrs: Intermittent infusion: 50mg every 6–8hrs (infuse over 15–20mins); usual max 400mg/day. Continuous IV infusion, or for Zollinger-Ellison: see full labeling. Renal impairment (CrCl<50mL/min): 50mg every 18–24hrs or more often if needed (intermittent only). Coincide a dose for end of hemodialysis.
Children
<1month: not recommended. ≥1month–16yrs: Treatment of duodenal ulcer: 2–4mg/kg per day in divided doses every 6–8hrs; max 50mg every 6–8hrs.
Zantac Injection Premixed Contraindications
Not Applicable
Zantac Injection Premixed Boxed Warnings
Not Applicable
Zantac Injection Premixed Warnings/Precautions
Warnings/Precautions
History of acute porphyria: not recommended. Renal impairment: reduce dose. Hepatic dysfunction. Discontinue if hepatic disorders occur. Monitor SGPT if on high-dose IV therapy for ≥5 days. Pregnancy (Cat.B). Nursing mothers.
Zantac Injection Premixed Pharmacokinetics
See Literature
Zantac Injection Premixed Interactions
Interactions
May increase triazolam, midazolam, glipizide, procainamide levels. May decrease ketoconazole, atazanavir, delaviridine, gefitnib levels. Monitor anticoagulants. May cause false (+) urine protein test with Multistix.
Zantac Injection Premixed Adverse Reactions
Adverse Reactions
Headache, GI disturbances, jaundice, hepatitis, rash; rare: CNS disturbances, arrhythmias, blurred vision, arthralgia, myalgia, inj site reactions, blood dyscrasias, anaphylaxis, angioneurotic edema, acute interstitial nephritis, bradycardia with rapid administration (IV); increased risk of pneumonia (see full labeling).
Zantac Injection Premixed Clinical Trials
See Literature
Zantac Injection Premixed Note
Not Applicable
Zantac Injection Premixed Patient Counseling
See Literature
