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Xifaxan 550mg Generic Name & Formulations
Legal Class
Rx
General Description
Rifaximin 550mg; tabs.
Pharmacological Class
Rifamycin.
How Supplied
Tabs—42, 60
Manufacturer
Mechanism of Action
Rifaximin is a semi-synthetic derivative of rifampin and acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase blocking one of the steps in transcription. This results in inhibition of bacterial protein synthesis and consequently inhibits the growth of bacteria.
Xifaxan 550mg Indications
Indications
Irritable bowel syndrome with diarrhea (IBS-D).
Xifaxan 550mg Dosage and Administration
Adult
≥18yrs: 550mg three times daily for 14 days. Recurrent episodes: can retreat up to two times with the same dosage regimen.
Children
<18yrs: not established.
Xifaxan 550mg Contraindications
Not Applicable
Xifaxan 550mg Boxed Warnings
Not Applicable
Xifaxan 550mg Warnings/Precautions
Warnings/Precautions
Not studied in patients with MELD scores >25 (only 8.6% of patients in the controlled trial had MELD >19). Severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.
Xifaxan 550mg Pharmacokinetics
Absorption
Mean Cmax: 2.4–4 ng/mL after a single and multiple doses (550 mg).
Distribution
Plasma protein binding ratio: 67.5% (healthy patients); 62% (hepatically impaired patients).
Elimination
Fecal (96.62%), renal (0.32%). Half-life: 5.6 hours (healthy patients); 6 hours (IBS-D patients).
Xifaxan 550mg Interactions
Interactions
Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.
Xifaxan 550mg Adverse Reactions
Adverse Reactions
Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.
Xifaxan 550mg Clinical Trials
See Literature
Xifaxan 550mg Note
Not Applicable
Xifaxan 550mg Patient Counseling
See Literature
Xifaxan 550mg Generic Name & Formulations
Legal Class
Rx
General Description
Rifaximin 550mg; tabs.
Pharmacological Class
Rifamycin.
How Supplied
Tabs—42, 60
Manufacturer
Mechanism of Action
Rifaximin is a semi-synthetic derivative of rifampin and acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase blocking one of the steps in transcription. This results in inhibition of bacterial protein synthesis and consequently inhibits the growth of bacteria.
Xifaxan 550mg Indications
Indications
Reduction in risk of overt hepatic encephalopathy recurrence.
Xifaxan 550mg Dosage and Administration
Adult
≥18yrs: 550mg twice daily.
Children
<18yrs: not established.
Xifaxan 550mg Contraindications
Not Applicable
Xifaxan 550mg Boxed Warnings
Not Applicable
Xifaxan 550mg Warnings/Precautions
Warnings/Precautions
Not studied in patients with MELD scores >25 (only 8.6% of patients in the controlled trial had MELD >19). Severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.
Xifaxan 550mg Pharmacokinetics
Absorption
Mean Cmax: 2.4–4 ng/mL after a single and multiple doses (550 mg).
Distribution
Plasma protein binding ratio: 67.5% (healthy patients); 62% (hepatically impaired patients).
Elimination
Fecal (96.62%), renal (0.32%). Half-life: 5.6 hours (healthy patients); 6 hours (IBS-D patients).
Xifaxan 550mg Interactions
Interactions
Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.
Xifaxan 550mg Adverse Reactions
Adverse Reactions
Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.
Xifaxan 550mg Clinical Trials
See Literature
Xifaxan 550mg Note
Not Applicable
Xifaxan 550mg Patient Counseling
See Literature
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