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Xifaxan 200mg Generic Name & Formulations
Legal Class
Rx
General Description
Rifaximin 200mg; tabs.
Pharmacological Class
Rifamycin.
How Supplied
Tabs—30
Manufacturer
Mechanism of Action
Rifaximin is a semi-synthetic derivative of rifampin and acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase blocking one of the steps in transcription. This results in inhibition of bacterial protein synthesis and consequently inhibits the growth of bacteria.
Xifaxan 200mg Indications
Indications
Travelers' diarrhea due to noninvasive E. coli.
Limitations of Use
Not for use if diarrhea is accompanied by fever or blood in stool, or if causative agent other than E. coli may be suspected (eg, C. jejuni, Shigella spp., Salmonella spp.).
Xifaxan 200mg Dosage and Administration
Adult
200mg 3 times daily for 3 days.
Children
Not established.
Xifaxan 200mg Contraindications
Not Applicable
Xifaxan 200mg Boxed Warnings
Not Applicable
Xifaxan 200mg Warnings/Precautions
Warnings/Precautions
Discontinue and reevaluate if diarrhea worsens or persists >24–48hrs. Not for treating systemic infections. Severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.
Xifaxan 200mg Pharmacokinetics
Absorption
Mean Cmax: 2.4–4 ng/mL after a single and multiple doses (550 mg).
Distribution
Plasma protein binding ratio: 67.5% (healthy patients); 62% (hepatically impaired patients).
Elimination
Fecal (96.62%), renal (0.32%). Half-life: 5.6 hours (healthy patients); 6 hours (IBS-D patients).
Xifaxan 200mg Interactions
Interactions
Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.
Xifaxan 200mg Adverse Reactions
Adverse Reactions
Flatulence, headache, abdominal pain, defecation urgency, nausea.
Xifaxan 200mg Clinical Trials
See Literature
Xifaxan 200mg Note
Not Applicable
Xifaxan 200mg Patient Counseling
See Literature
