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Urso Generic Name & Formulations
Legal Class
Rx
General Description
Ursodiol 250mg; tabs.
Pharmacological Class
Bile acid.
See Also
How Supplied
Tabs—100; Forte—100
Manufacturer
Generic Availability
YES
Urso Indications
Indications
Primary biliary cirrhosis.
Urso Dosage and Administration
Adult
Take with food. 13–15mg/kg per day in 2–4 divided doses.
Children
Not established.
Urso Contraindications
Contraindications
Complete biliary obstruction.
Urso Boxed Warnings
Not Applicable
Urso Warnings/Precautions
Warnings/Precautions
Variceal bleeding, hepatic encephalopathy, ascites, and/or need for an urgent liver transplant: give appropriate specific treatment. Monitor liver function and bilirubin monthly for 3 months after starting therapy, then every 6 months thereafter; consider discontinuing if levels increase significantly with history of stable liver function. Monitor and maintain bile flow. Enteroliths in those with risk for intestinal stenosis or stasis. Withhold and evaluate if obstructive GI symptoms occur. Pregnancy. Nursing mothers.
Urso Pharmacokinetics
Elimination
Primarily fecal.
Urso Interactions
Interactions
Reduced absorption with bile acid sequestrants (eg, cholestyramine, colestipol), and aluminum-containing antacids. Estrogens, oral contraceptives, clofibrate, other lipid-lowering drugs may reduce effectiveness of ursodiol by increasing hepatic cholesterol secretion.
Urso Adverse Reactions
Adverse Reactions
Abdominal discomfort or pain, alopecia, diarrhea, nausea, pruritus, rash, leukopenia, elevated creatinine or blood glucose, thrombocytopenia.
Urso Clinical Trials
See Literature
Urso Note
Not Applicable
Urso Patient Counseling
See Literature
