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Suprep Generic Name & Formulations
Legal Class
Rx
General Description
Sodium sulfate 17.5g, potassium sulfate 3.13g, magnesium sulfate 1.6g; per 6oz of soln (for adults); sodium sulfate 13.13g, potassium sulfate 2.35g, magnesium sulfate 1.2g; per 4.5oz of soln (for pediatrics).
Pharmacological Class
Osmotic laxative.
How Supplied
Bowel prep kit (adults)—1 (2 x 6oz bottles + mixing container); Bowel prep kit (pediatrics)—1 (2 x 4.5oz bottles + mixing container)
Manufacturer
Generic Availability
NO
Suprep Indications
Indications
Bowel cleansing before colonoscopy.
Suprep Dosage and Administration
Adult
Split-dose regimen (1st dose start the evening before colonoscopy): use 1 bottle of 6oz and dilute to 16oz with water and drink entire amount. Drink 32oz of water over the next hour; (2nd dose start next morning): repeat using the 2nd bottle. Complete prep at least 2hrs before colonoscopy.
Children
<12yrs: not established. 12–16yrs: Split-dose regimen (1st dose start the evening before colonoscopy): use 1 bottle of 4.5oz and dilute to 12oz with water and drink entire amount. Drink 24oz of water over the next hour; (2nd dose start next morning): repeat using the 2nd bottle. Complete prep at least 2hrs before colonoscopy.
Suprep Contraindications
Contraindications
GI obstruction or ileus. Bowel perforation. Toxic colitis. Toxic megacolon. Gastric retention.
Suprep Boxed Warnings
Not Applicable
Suprep Warnings/Precautions
Warnings/Precautions
Maintain adequate hydration. Correct fluid and electrolyte abnormalities before therapy. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. History of QT prolongation, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. Gout. History of seizures. Hyponatremia. Inflammatory bowel disease. Colonic mucosal ulcerations. Ischemic colitis. Severe ulcerative colitis. Risk of regurgitation or aspiration in gag reflex impairment or other swallowing abnormalities. Elderly. Pregnancy. Nursing mothers.
Suprep Pharmacokinetics
See Literature
Suprep Interactions
Interactions
Caution with concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal: may increase risk of seizures. Caution with drugs that may increase risk for fluid or electrolyte disturbances, arrhythmias or QT prolongation. Administer oral medications at least 1hr before starting each dose of Suprep. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2hrs before and not less than 6hrs after Suprep to avoid chelation with magnesium. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate).
Suprep Adverse Reactions
Adverse Reactions
Overall discomfort, abdominal distention/pain, nausea, vomiting; transient elevated uric acid, renal injury.
Suprep Clinical Trials
See Literature
Suprep Note
Not Applicable
Suprep Patient Counseling
See Literature
