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Relistor Generic Name & Formulations
Legal Class
Rx
General Description
Methylnaltrexone bromide 150mg; tabs.
Pharmacological Class
Opioid antagonist (peripheral).
See Also
How Supplied
Tabs—60, 90; Single-use vial (12mg/0.6mL)—1; Prefilled syringes (8mg/0.4mL)—7; Prefilled syringes (12mg/0.6mL)—1, 7
Manufacturer
Generic Availability
NO
Relistor Indications
Indications
Opioid-induced constipation (OIC) in adults with chronic non-cancer pain, including chronic pain related to prior cancer or its treatment in patients who do not require frequent opioid dosage escalation.
Relistor Dosage and Administration
Adult
Discontinue all maintenance laxatives prior to initiation; may be used if suboptimal methylnaltrexone response after 3 days. Reevaluate if opioid regimen is changed. Take on an empty stomach with water ≥30mins before first meal of day. 450mg once daily in the AM. Moderate or severe renal (CrCl<60mL/min) or hepatic (Child-Pugh B or C) impairment: 150mg once daily.
Children
Not established.
Relistor Contraindications
Contraindications
Known or suspected GI obstruction and at increased risk of recurrent obstruction.
Relistor Boxed Warnings
Not Applicable
Relistor Warnings/Precautions
Warnings/Precautions
Discontinue if concurrent opioid pain medication is also discontinued. GI perforation; monitor for severe, persistent, or worsening abdominal pain; discontinue if occurs. Discontinue if severe or persistent diarrhea occurs. Increased risk of opioid withdrawal and/or reduced analgesia in those with blood-brain barrier disruptions; monitor for symptoms. Bowel movement may occur within 30 mins of dosing. Elderly. Pregnancy. Nursing mothers: not recommended.
Relistor Pharmacokinetics
See Literature
Relistor Interactions
Interactions
Potential additive effects and increased risk of opioid withdrawal with concomitant other opioid antagonists; avoid.
Relistor Adverse Reactions
Adverse Reactions
Abdominal pain, flatulence, nausea, dizziness, diarrhea, headache, abdominal distention, vomiting, hyperhidrosis, anxiety, muscle spasms, rhinorrhea, chills, tremor, hot flush; GI perforation, opioid withdrawal.
Relistor Clinical Trials
See Literature
Relistor Note
Not Applicable
Relistor Patient Counseling
See Literature
