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Reglan Generic Name & Formulations
Legal Class
Rx
General Description
Metoclopramide (as HCl) 5mg, +10mg; +scored tabs.
Pharmacological Class
Dopamine-2 receptor antagonist.
See Also
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Reglan Indications
Indications
Symptomatic refractory GERD.
Reglan Dosage and Administration
Adult
Give 30mins before meals and at bedtime. Treat for 4–12 weeks. Continuous dosing: 10–15mg four times daily; max 60mg/day. Intermittent dosing: single dose up to 20mg prior to provoking situation. Elderly: 5mg four times daily; max 60mg/day. Moderate-to-severe renal or hepatic impairment, CYP2D6 poor metabolizers, concomitant strong CYP2D6 inhibitors: 5mg four times daily or 10mg three times daily; max 30mg/day. ESRD (including dialysis): 5mg four times daily or 10mg twice daily; max 20mg/day.
Children
Not recommended.
Reglan Contraindications
Contraindications
History of tardive dyskinesia (TD) or a dystonic reaction to metoclopramide. When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma or other catecholamine-releasing paragangliomas. Epilepsy.
Reglan Boxed Warnings
Boxed Warning
Tardive dyskinesia.
Reglan Warnings/Precautions
Warnings/Precautions
Increased risk of TD with long-term use; avoid treatment >12 weeks. Diabetes mellitus. Discontinue if signs/symptoms of TD, extrapyramidal symptoms (EPS), parkinsonian symptoms, motor restlessness, or neuroleptic malignant syndrome (NMS) occurs. Avoid in Parkinson's disease, depression, hypertension. Cirrhosis. CHF. Renal or hepatic impairment. NADH-cytochrome b5 reductase deficiency. G6PD deficiency. CYP2D6 poor metabolizers. Elderly (esp. women). Neonates. Pregnancy. Nursing mothers: monitor infants.
Reglan Pharmacokinetics
See Literature
Reglan Interactions
Interactions
Avoid concomitant drugs that can cause or potentially affect TD, EPS, or NMS (eg, antipsychotics). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, bupropion, fluoxetine, paroxetine); reduce dose (see Adult). Increased risk of hypertension with MAOIs; avoid. Increased risk of CNS depression with alcohol, sedatives, hypnotics, opiates, anxiolytics. Antagonized by drugs that impair GI motility (eg, antidiarrheals, anticholinergics, opiates). Avoid concomitant dopaminergic drugs (eg, apomorphine, bromocriptine, levodopa, ropinirole). May potentiate succinylcholine, mivacurium, sirolimus, tacrolimus, cyclosporine; monitor and adjust dose. May antagonize digoxin (adjust dose), atovaquone, posaconazole (oral susp), fosfomycin; monitor. Concomitant insulin: monitor and adjust dose.
Reglan Adverse Reactions
Adverse Reactions
Restlessness, drowsiness, fatigue, lassitude; TD, EPS, parkinsonism, akathisia, seizures, hallucinations, NMS, hypertension (discontinue if occurs), fluid retention (discontinue if occurs), hyperprolactinemia, hypersensitivity reactions.
Reglan Clinical Trials
See Literature
Reglan Note
Not Applicable
Reglan Patient Counseling
See Literature
Reglan Generic Name & Formulations
Legal Class
Rx
General Description
Metoclopramide (as HCl) 5mg, +10mg; +scored tabs.
Pharmacological Class
Dopamine-2 receptor antagonist.
See Also
How Supplied
Tabs—100; Single-use vial—contact supplier
Manufacturer
Generic Availability
YES
Reglan Indications
Indications
Relief of symptoms associated with acute and recurrent diabetic gastroparesis.
Reglan Dosage and Administration
Adult
Give 30mins before meals and at bedtime. Treat for 2–8 weeks. 10mg four times daily; max 40mg/day. Elderly: 5mg four times daily; max 40mg/day. Moderate-to-severe renal or hepatic impairment, CYP2D6 poor metabolizers, concomitant strong CYP2D6 inhibitors: 5mg four times daily; max 20mg/day. ESRD (including dialysis): 5mg twice daily; max 10mg/day.
Children
Not recommended.
Reglan Contraindications
Contraindications
History of tardive dyskinesia (TD) or a dystonic reaction to metoclopramide. When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma or other catecholamine-releasing paragangliomas. Epilepsy.
Reglan Boxed Warnings
Boxed Warning
Tardive dyskinesia.
Reglan Warnings/Precautions
Warnings/Precautions
Increased risk of TD with long-term use; avoid treatment >12 weeks. Diabetes mellitus. Discontinue if signs/symptoms of TD, extrapyramidal symptoms (EPS), parkinsonian symptoms, motor restlessness, or neuroleptic malignant syndrome (NMS) occurs. Avoid in Parkinson's disease, depression, hypertension. Cirrhosis. CHF. Renal or hepatic impairment. NADH-cytochrome b5 reductase deficiency. G6PD deficiency. CYP2D6 poor metabolizers. Elderly (esp. women). Neonates. Pregnancy. Nursing mothers: monitor infants.
Reglan Pharmacokinetics
See Literature
Reglan Interactions
Interactions
Avoid concomitant drugs that can cause or potentially affect TD, EPS, or NMS (eg, antipsychotics). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, bupropion, fluoxetine, paroxetine); reduce dose (see Adult). Increased risk of hypertension with MAOIs; avoid. Increased risk of CNS depression with alcohol, sedatives, hypnotics, opiates, anxiolytics. Antagonized by drugs that impair GI motility (eg, antidiarrheals, anticholinergics, opiates). Avoid concomitant dopaminergic drugs (eg, apomorphine, bromocriptine, levodopa, ropinirole). May potentiate succinylcholine, mivacurium, sirolimus, tacrolimus, cyclosporine; monitor and adjust dose. May antagonize digoxin (adjust dose), atovaquone, posaconazole (oral susp), fosfomycin; monitor. Concomitant insulin: monitor and adjust dose.
Reglan Adverse Reactions
Adverse Reactions
Restlessness, drowsiness, fatigue, lassitude; TD, EPS, parkinsonism, akathisia, seizures, hallucinations, NMS, hypertension (discontinue if occurs), fluid retention (discontinue if occurs), hyperprolactinemia, hypersensitivity reactions.
Reglan Clinical Trials
See Literature
Reglan Note
Not Applicable
Reglan Patient Counseling
See Literature
