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Propantheline Bromide Generic Name & Formulations
Legal Class
Rx
General Description
Propantheline bromide 15mg; tabs.
Pharmacological Class
Anticholinergic.
How Supplied
Tabs—100
Manufacturer
Propantheline Bromide Indications
Indications
Adjunctive therapy in the treatment of peptic ulcer.
Propantheline Bromide Dosage and Administration
Adult
15mg taken 30mins before each meal and 30mg at bedtime. Total daily dose: 75mg.
Children
Not recommended.
Propantheline Bromide Contraindications
Contraindications
Glaucoma. GI obstruction (eg, pyloroduodenal stenosis, achalasia, paralytic ileus). GU obstruction (eg, bladder-neck obstruction due to prostatic hypertrophy). Intestinal atony of elderly or debilitated. Severe ulcerative colitis. Toxic megacolon. Unstable cardiovascular adjustment in acute hemorrhage. Myasthenia gravis.
Propantheline Bromide Boxed Warnings
Not Applicable
Propantheline Bromide Warnings/Precautions
Warnings/Precautions
High environmental temperature. Monitor for diarrhea; may be symptom of incomplete intestinal obstruction. Heart disease. CHF. Cardiac tachyarrhythmias. Hypertension. Hiatal hernia associated with reflux esophagitis. Autonomic neuropathy. Hepatic or renal disease. Hyperthyroidism. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propantheline Bromide Pharmacokinetics
See Literature
Propantheline Bromide Interactions
Interactions
Additive anticholinergic effects with concomitant belladonna alkaloids, narcotic analgesics (eg, meperidine), Class I antiarrhythmics (eg, disopyramide, procainamide, quinidine), antihistamines, phenothiazines (may potentiated sedative effects), tricyclic antidepressants, other anticholinergics. Increased intraocular pressure with concomitant corticosteroids. May potentiate slow-dissolving digoxin tablets; use rapidly-dissolving digoxin tablets instead.
Propantheline Bromide Adverse Reactions
Adverse Reactions
Drying of salivary secretions, decreased sweating, ophthalmic effects (eg, blurred vision, mydriasis, cycloplegia, increased ocular tension), urinary hesitancy and retention, tachycardia, palpitations, loss of sense of taste, headache, nervousness, mental confusion, drowsiness, weakness, dizziness, insomnia, GI upset, constipation, bloating, impotence, lactation suppression, allergic reactions.
Propantheline Bromide Clinical Trials
See Literature
Propantheline Bromide Note
Notes
Formerly known under the brand name Pro-Banthine.
Propantheline Bromide Patient Counseling
See Literature
