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Promethazine Hcl Rectal Suppositories Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 12.5mg, 25mg, 50mg.
Pharmacological Class
Phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Promethazine Hcl Rectal Suppositories Indications
Indications
Motion sickness. Perioperative nausea & vomiting.
Promethazine Hcl Rectal Suppositories Dosage and Administration
Adult
Motion sickness: 25mg 30–60mins before travel; may repeat in 8–12hrs; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6hr intervals.
Children
<2yrs: see Contraindications. Motion sickness: ≥2yrs: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6hr intervals.
Promethazine Hcl Rectal Suppositories Contraindications
Contraindications
Children <2yrs. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children.
Promethazine Hcl Rectal Suppositories Boxed Warnings
Not Applicable
Promethazine Hcl Rectal Suppositories Warnings/Precautions
Warnings/Precautions
Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2yrs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Promethazine Hcl Rectal Suppositories Pharmacokinetics
See Literature
Promethazine Hcl Rectal Suppositories Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results.
Promethazine Hcl Rectal Suppositories Adverse Reactions
Adverse Reactions
Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal).
Promethazine Hcl Rectal Suppositories Clinical Trials
See Literature
Promethazine Hcl Rectal Suppositories Note
Notes
Formerly known under the brand names Phenergan (tabs, supps); Promethacon (supps).
Promethazine Hcl Rectal Suppositories Patient Counseling
See Literature
