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Prochlorperazine Generic Name & Formulations
Legal Class
Rx
General Description
Prochlorperazine (as maleate) 5mg, 10mg; tabs.
Pharmacological Class
Piperazine phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Prochlorperazine Indications
Indications
Short-term generalized anxiety.
Prochlorperazine Dosage and Administration
Adult
5mg 3–4 times daily; max 20mg/day. Do not use >12 weeks.
Children
Not recommended.
Prochlorperazine Contraindications
Contraindications
Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.
Prochlorperazine Boxed Warnings
Not Applicable
Prochlorperazine Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Prochlorperazine Pharmacokinetics
See Literature
Prochlorperazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.
Prochlorperazine Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.
Prochlorperazine Clinical Trials
See Literature
Prochlorperazine Note
Notes
Formerly known under the brand name Compazine.
Prochlorperazine Patient Counseling
See Literature
Prochlorperazine Generic Name & Formulations
Legal Class
Rx
General Description
Prochlorperazine (as maleate) 5mg, 10mg; tabs.
Pharmacological Class
Piperazine phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Prochlorperazine Indications
Indications
Severe nausea and vomiting.
Prochlorperazine Dosage and Administration
Adult
Oral: 5–10mg 3–4 times daily; usual max 40mg/day. Rectal: 25mg twice daily.
Children
<2yrs or <20lbs: not recommended. Oral: 20–29lbs: 2½mg once or twice daily; max 7.5mg/day. 30–39lbs: 2½mg 2–3 times daily; max 10mg/day. 40–85lbs: 2½mg 3 times daily or 5mg twice daily; max 15mg/day.
Prochlorperazine Contraindications
Contraindications
Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.
Prochlorperazine Boxed Warnings
Not Applicable
Prochlorperazine Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Prochlorperazine Pharmacokinetics
See Literature
Prochlorperazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.
Prochlorperazine Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.
Prochlorperazine Clinical Trials
See Literature
Prochlorperazine Note
Notes
Formerly known under the brand name Compazine.
Prochlorperazine Patient Counseling
See Literature
Prochlorperazine Generic Name & Formulations
Legal Class
Rx
General Description
Prochlorperazine (as maleate) 5mg, 10mg; tabs.
Pharmacological Class
Piperazine phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Prochlorperazine Indications
Indications
Schizophrenia.
Prochlorperazine Dosage and Administration
Adult
Mild conditions: 5–10mg 3–4 times daily. Moderate-to-severe conditions (closely supervised): Initially 10mg 3–4 times daily, may increase gradually every 2–3 days; usual range 50–75mg/day. Severe conditions: usual range 100–150mg daily.
Children
<2yrs or <20lbs: not recommended. 2yrs–5yrs: Initially 2.5mg 2–3 times daily; max 10mg first day, then max 20mg/day. 6–12yrs: Initially 2.5mg 2–3 times daily; max 10mg first day, then max 25mg/day.
Prochlorperazine Contraindications
Contraindications
Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.
Prochlorperazine Boxed Warnings
Not Applicable
Prochlorperazine Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Prochlorperazine Pharmacokinetics
See Literature
Prochlorperazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.
Prochlorperazine Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.
Prochlorperazine Clinical Trials
See Literature
Prochlorperazine Note
Notes
Formerly known under the brand name Compazine.
Prochlorperazine Patient Counseling
See Literature
