Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Perphenazine Generic Name & Formulations
Legal Class
Rx
General Description
Perphenazine 2mg, 4mg, 8mg, 16mg; tabs.
Pharmacological Class
Piperazinyl phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Perphenazine Indications
Indications
Severe nausea and vomiting.
Perphenazine Dosage and Administration
Adult
8–16mg/day in divided doses; may use 24mg, if needed. Reduce dose as soon as possible.
Children
Not recommended.
Perphenazine Contraindications
Contraindications
Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.
Perphenazine Boxed Warnings
Not Applicable
Perphenazine Warnings/Precautions
Warnings/Precautions
CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Perphenazine Pharmacokinetics
See Literature
Perphenazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.
Perphenazine Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.
Perphenazine Clinical Trials
See Literature
Perphenazine Note
Notes
Formerly known under the brand name Trilafon.
Perphenazine Patient Counseling
See Literature
Perphenazine Generic Name & Formulations
Legal Class
Rx
General Description
Perphenazine 2mg, 4mg, 8mg, 16mg; tabs.
Pharmacological Class
Piperazinyl phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Perphenazine Indications
Indications
Manifestations of psychotic disorders.
Perphenazine Dosage and Administration
Adult
Nonhospitalized: initially 4–8mg 3 times daily; then reduce to lowest effective dose. Hospitalized: 8–16mg 2–4 times daily; max 64mg per day.
Children
Not recommended.
Perphenazine Contraindications
Contraindications
Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.
Perphenazine Boxed Warnings
Not Applicable
Perphenazine Warnings/Precautions
Warnings/Precautions
CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.
Perphenazine Pharmacokinetics
See Literature
Perphenazine Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.
Perphenazine Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.
Perphenazine Clinical Trials
See Literature
Perphenazine Note
Notes
Formerly known under the brand name Trilafon.
Perphenazine Patient Counseling
See Literature
