Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Osmoprep Generic Name & Formulations
Legal Class
Rx
General Description
Sodium phosphate (as monobasic monohydrate and dibasic anhydrous) 1.5g; tabs; gluten-free.
Pharmacological Class
Osmotic laxative.
How Supplied
Tabs—100
Manufacturer
Osmoprep Indications
Indications
Bowel cleansing prior to colonoscopy.
Osmoprep Dosage and Administration
Adult
≥18yrs: Evening before colonoscopy: 4 tabs with 8oz of clear liq every 15 mins for a total of 20 tabs; repeat on day of colonoscopy 3–5 hrs before procedure for a total of 12 tabs. Wait 7 days before retreating.
Children
<18yrs: not recommended.
Osmoprep Contraindications
Contraindications
Biopsy-proven acute phosphate nephropathy.
Osmoprep Boxed Warnings
Boxed Warning
Renal disease and acute phosphate nephropathy.
Osmoprep Warnings/Precautions
Warnings/Precautions
Elderly, hypovolemia, increased bowel transit time, active colitis, baseline kidney disease: increased risk of acute phosphate nephropathy. Severe renal insufficiency (CrCl<30mL/min). Impaired renal function. History of acute phosphate nephropathy. CHF. Unstable angina. Arrhythmias (consider pre-dose and post-colonoscopy ECGs). History of cardiomyopathy. Prolonged QT. Recent MI. Ascites. Gastric retention. Ileus or acute obstruction or pseudo-obstruction. Gastric bypass or stapling surgery. Severe chronic constipation. Bowel perforation. Toxic megacolon. Hypomotility syndrome. Inflammatory bowel disease. Correct electrolyte abnormalities before use. Consider doing baseline and post-colonoscopy labs in patients at increased risk. History or risk of seizures. Maintain adequate hydration. Pregnancy (Cat.C).
Osmoprep Pharmacokinetics
See Literature
Osmoprep Interactions
Interactions
Avoid concomitant purgative agents (esp. sodium phosphate). Caution with drugs that prolong QT interval, affect electrolytes or renal function (eg, diuretics, ACEIs, ARBs, NSAIDs), or lower seizure threshold. May reduce drug absorption.
Osmoprep Adverse Reactions
Adverse Reactions
Abdominal bloating/pain, nausea, vomiting, electrolyte imbalances, dizziness, headache; rare: renal failure, acute phosphate nephropathy, nephrocalcinosis.
Osmoprep Clinical Trials
See Literature
Osmoprep Note
Not Applicable
Osmoprep Patient Counseling
See Literature
