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Nexium Iv Generic Name & Formulations
Legal Class
Rx
General Description
Esomeprazole (as sodium) 20mg, 40mg; per vial; pwd for IV inj after reconstitution or for infusion after reconstitution and dilution.
Pharmacological Class
Proton pump inhibitor.
See Also
How Supplied
Caps—30, 90, 1000; Susp—30 packets; IV soln (single-use vial)—10
Manufacturer
Generic Availability
YES
Nexium Iv Indications
Indications
Short-term (up to 10 days) alternative to oral therapy for GERD with erosive esophagitis. Risk reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy in adults.
Nexium Iv Dosage and Administration
Adult
GERD: Inject IV over ≥3 mins or infuse IV over 10–30 mins. ≥18yrs: 20–40mg once daily for ≤10 days; switch to oral form when feasible. Severe hepatic impairment: max 20mg/day. Risk reduction: initially 80mg IV over 30 mins, then 8mg/hr continuous infusion over 71.5 hrs; switch to oral form when feasible. Hepatic impairment (mild to moderate): max continuous infusion at 6mg/hr; (severe): max 4mg/hr.
Children
Infuse IV over 10–30 mins. <1 month: not recommended. 1 month–<1yr: 0.5mg/kg. 1yr–17yrs: <55kg: 10mg; ≥55kg: 20mg.
Nexium Iv Contraindications
Contraindications
Concomitant rilpivirine-containing drugs.
Nexium Iv Boxed Warnings
Not Applicable
Nexium Iv Warnings/Precautions
Warnings/Precautions
Symptomatic response does not preclude gastric malignancy. Discontinue and evaluate if acute tubulointerstitial nephritis, severe cutaneous adverse reactions, or cutaneous/systemic lupus erythematosus occurs. Long-term therapy (eg, >3yrs) may lead to malabsorption/deficiency of Vit. B12. Monitor magnesium levels during prolonged therapy. Consider monitoring magnesium, calcium levels in those with preexisting risk of hypocalcemia (eg, hypoparathyroidism). Increased risk of fundic gland polyps with long-term use (esp. >1yr) or osteoporosis-related fractures (hip, wrist or spine) with long-term (>1yr) and multiple daily dose PPI therapy. Use lowest dose for shortest duration appropriate to condition. Pregnancy. Nursing mothers.
Nexium Iv Pharmacokinetics
See Literature
Nexium Iv Interactions
Interactions
Avoid concomitant St. John's wort, rifampin, nelfinavir. May potentiate saquinavir; monitor for toxicity. May reduce absorption of gastric pH-dependent drugs (eg, iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole). Antagonizes clopidogrel; consider alternative anti-platelets. May affect drugs metabolized by CYP2C19. May potentiate digoxin, tacrolimus, cilostazol (consider reduced dose), citalopram (limit dose to max 20mg/day), high-dose methotrexate (consider temporary withdrawal of PPI). Caution with drugs that may cause hypomagnesemia (eg, digoxin, diuretics); monitor. Monitor INR, PT with warfarin. Potentiated by voriconazole; may need to adjust esomeprazole dose in Zollinger-Ellison syndrome. May give antacids concomitantly. May cause false (+) results in diagnostic investigations for neuroendocrine tumors; discontinue esomeprazole 14 days prior to CgA level assessment; may need repeat test. May cause false (+) results with secretin stimulation test or urine tests for tetrahydrocannabinol.
Nexium Iv Adverse Reactions
Adverse Reactions
Headache, diarrhea, abdominal pain, nausea, flatulence, constipation, dry mouth, inj site reactions, dizziness, vertigo; possible C. difficile-associated diarrhea; rare: rash, allergic reactions, hypomagnesemia and mineral metabolism. Children: Also, somnolence, regurgitation, tachypnea, increased ALT.
Nexium Iv Clinical Trials
See Literature
Nexium Iv Note
Notes
See Biaxin for more information on clarithromycin. See Amoxil for more information on amoxicillin.
Nexium Iv Patient Counseling
See Literature
