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Moviprep Generic Name & Formulations
Legal Class
Rx
General Description
Polyethylene glycol 3350 200g, sodium sulfate 15g, sodium chloride 5.38g, potassium chloride 2.03g, ascorbic acid 9.4g, sodium ascorbate 11.8g; per 2L of soln; pwd for reconstitution; contains phenylalanine 131mg/treatment; lemon-flavor.
Pharmacological Class
Osmotic laxative.
How Supplied
Carton—1 (disposable container w. 4 pouches)
Manufacturer
Generic Availability
NO
Moviprep Indications
Indications
Bowel cleansing before colonoscopy.
Moviprep Dosage and Administration
Adult
No solid food from start of prep. For both regimens start the evening before colonoscopy. Split-dose regimen: drink 240mL every 15mins over 1hr until 1L consumed, follow with 480mL of clear liquids; in the AM (start ≥3.5hrs before colonoscopy), drink 2nd liter over 1hr, then drink 480mL of clear liquids at least 2hrs before colonoscopy; or, Evening-only regimen: start at least 3.5hrs before bedtime; drink 240mL every 15mins over 1hr until 1L consumed, then drink 2nd liter 1.5hrs later over 1hr; in addition, drink 1L of clear liquids.
Children
<18yrs: not established.
Moviprep Contraindications
Contraindications
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.
Moviprep Boxed Warnings
Not Applicable
Moviprep Warnings/Precautions
Warnings/Precautions
Correct fluid/electrolyte abnormalities prior to initiation. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, cardiomyopathy, or electrolyte imbalance: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment: perform baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex or swallowing abnormalities: risk for regurgitation or aspiration. G6PD deficiency. Phenylketonuria. Maintain adequate hydration. Pregnancy. Nursing mothers.
Moviprep Pharmacokinetics
See Literature
Moviprep Interactions
Interactions
Avoid concomitant with starch-based thickeners. Caution with drugs that increase risk of fluid/electrolyte abnormalities, renal impairment, seizures, arrhythmias, or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of mucosal ulceration, ischemic colitis. Oral drugs administered within 1hr of start of MoviPrep may not be absorbed.
Moviprep Adverse Reactions
Adverse Reactions
Malaise, nausea, vomiting, abdominal distension and pain (give slowly or discontinue if occurs), anal discomfort, thirst, sleep disorder, rigors, hunger, dizziness; hypersensitivity reactions; rare: arrhythmias, seizures.
Moviprep Clinical Trials
See Literature
Moviprep Note
Not Applicable
Moviprep Patient Counseling
See Literature
