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Motofen Generic Name & Formulations
Legal Class
CIV
General Description
Difenoxin HCl 1mg, atropine sulfate 0.025mg; tabs.
Pharmacological Class
Opioid + anticholinergic.
How Supplied
Tabs—50, 100
Manufacturer
Motofen Indications
Indications
Adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.
Motofen Dosage and Administration
Adult
Initially 2mg, then 1mg after each loose stool or 1mg every 3–4 hours as needed. Max 8mg/24hrs. Discontinue use if no improvement after 48hrs.
Children
Not recommended.
Motofen Contraindications
Contraindications
Diarrhea associated with organisms that penetrate the intestinal mucosa (eg, toxigenic E. coli, Salmonella species, Shigella) and pseudomembranous colitis associated with broad spectrum antibiotics. Children <2yrs old. Jaundice.
Motofen Boxed Warnings
Not Applicable
Motofen Warnings/Precautions
Warnings/Precautions
Monitor fluid and electrolyte balance. Withhold dose if severe dehydration or electrolyte imbalance occurs. Acute ulcerative colitis; discontinue if abdominal distention occurs or if other untoward symptoms develop. Advanced hepatorenal disease or abnormal liver function tests; hepatic coma may be precipitated. Children with Down's syndrome. Pregnancy (Cat.C). Nursing mothers: not recommended.
Motofen Pharmacokinetics
See Literature
Motofen Interactions
Interactions
Avoid in patients in whom anticholinergic drugs are contraindicated. Hypertensive crisis possible with concomitant MAOIs. May potentiate barbiturates, tranquilizers, narcotics, alcohol; monitor.
Motofen Adverse Reactions
Adverse Reactions
GI upset, dry mouth, epigastric distress, constipation, dizziness, drowsiness, headache, tiredness, nervousness, insomnia, confusion.
Motofen Clinical Trials
See Literature
Motofen Note
Not Applicable
Motofen Patient Counseling
See Literature
