Metoclopramide Injection

Diabetic gastroparesis (early manifestations): initiate with oral form; (severe symptoms): initiate with IM or IV inj. May give 10mg doses slowly by IV route over a 1–2 minute period. Administration up to 10 days may be needed, at which time oral form may be instituted. Prophylaxis of nausea/vomiting: administer by IV infusion slowly over at least 15mins; give 30mins before chemotherapy and repeat every 2hrs for 2 doses, then every 3hrs for 3 doses. If highly emetogenic drugs used alone or in combination (eg, cisplatin, dacarbazine): give 2mg/kg for initial 2 doses; if less emetogenic drugs: 1mg/kg per dose may suffice. For doses >10mg: dilute in 50mL of a parenteral soln. Prophylaxis of post-op nausea/vomiting: give by IM inj near the end of surgery. Usually 10mg, however, 20mg doses may be used. Renal impairment (CrCl <40mL/min): initiate at 50% of dose.