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Lomotil Generic Name & Formulations
Legal Class
CV
General Description
Diphenoxylate HCl 2.5mg, atropine sulfate 0.025mg; tabs.
Pharmacological Class
Opioid + anticholinergic.
How Supplied
Tabs—100
Manufacturer
Lomotil Indications
Indications
Adjunct therapy in the management of diarrhea.
Lomotil Dosage and Administration
Adult
≥13yrs: 2 tabs 4 times daily until diarrhea is controlled; max 20mg/day. Maintenance: 2 tabs daily. Discontinue if no improvement within 10 days after treatment with max dose.
Children
<13yrs: not established.
Lomotil Contraindications
Contraindications
Age <6yrs (risks of respiratory and/or CNS depression). Diarrhea associated with pseudomembranous enterocolitis or other enterotoxin-producing bacteria due to risk of GI complications (including sepsis). Obstructive jaundice.
Lomotil Boxed Warnings
Not Applicable
Lomotil Warnings/Precautions
Warnings/Precautions
Dehydration. Electrolyte imbalance. Acute ulcerative colitis; discontinue if toxic megacolon occurs. Hepatic or renal impairment. Drug abusers. Pregnancy. Nursing mothers.
Lomotil Pharmacokinetics
See Literature
Lomotil Interactions
Interactions
Avoid alcohol. Concomitant MAOIs may cause hypertensive crisis; avoid use. Potentiates sedation with alcohol or other CNS depressants (eg, barbiturates, benzodiazepines, sedatives/hypnotics, anxiolytics, tranquilizers, general anesthetics, antipsychotics, opioids, buspirone, antihistamines, muscle relaxants); monitor closely. May delay elimination of other drugs metabolized by CPY450.
Lomotil Adverse Reactions
Adverse Reactions
Nausea, vomiting, abdominal discomfort, paralytic ileus, toxic megacolon, dizziness, drowsiness, headache, euphoria, tachycardia, numbness of extremities, pruritus, urticaria, angioneurotic edema, anticholinergic effects; respiratory depression (overdosage), atropinism (esp. in pediatrics with Down's syndrome).
Lomotil Clinical Trials
See Literature
Lomotil Note
Not Applicable
Lomotil Patient Counseling
See Literature
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