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Granisetron Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Granisetron (as HCl) 1mg/mL (contains benzyl alcohol); 0.1mg/mL (preservative-free); IV inj.
Pharmacological Class
Selective 5-HT3 receptor antagonist.
See Also
How Supplied
Contact supplier.
Manufacturer
Granisetron Hcl Injection Indications
Indications
Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin). Prevention and treatment of post-op nausea and vomiting.
Granisetron Hcl Injection Dosage and Administration
Adults and Children
Chemotherapy: give as an undiluted IV injection over 30 seconds or as a diluted IV infusion over 5 minutes. <2 years: not recommended; ≥2 years: 10micrograms/kg starting within 30 minutes of initiating chemotherapy, only on the days chemotherapy is given. Post-op (adults): infuse 1mg undiluted IV over 30 seconds. For prevention, give before induction of anesthesia or immediately before reversal of anesthesia. Post-op (children): not recommended.
Granisetron Hcl Injection Contraindications
Not Applicable
Granisetron Hcl Injection Boxed Warnings
Not Applicable
Granisetron Hcl Injection Warnings/Precautions
Warnings/Precautions
Abdominal surgery. May mask progressive ileus and/or gastric distention. Pre-existing arrhythmias or cardiac conduction disorders. Cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities: increased risk of QT prolongation. Pregnancy (Cat.B). Nursing mothers.
Granisetron Hcl Injection Pharmacokinetics
See Literature
Granisetron Hcl Injection Interactions
Interactions
Caution with drugs that affect CYP450 or prolong the QT interval.
Granisetron Hcl Injection Adverse Reactions
Adverse Reactions
Headache, asthenia, diarrhea, constipation; QT prolongation.
Granisetron Hcl Injection Clinical Trials
See Literature
Granisetron Hcl Injection Note
Notes
Formerly known under the brand name Kytril.
Granisetron Hcl Injection Patient Counseling
See Literature
