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Golytely Generic Name & Formulations
Legal Class
Rx
General Description
Polyethylene glycol 3350 236g, sodium chloride 5.86g, potassium chloride 2.97g, sodium bicarbonate 6.74g, sodium sulfate 22.74g; per 4 liter; pwd for reconstitution.
Pharmacological Class
Isosmotic bowel cleanser.
How Supplied
Disposable jug (4L)—1
Manufacturer
Generic Availability
YES
Golytely Indications
Indications
Bowel cleansing before colonscopy and barium enema x-ray examination.
Golytely Dosage and Administration
Adult
May consume water or clear liquids during and after completion of bowel prep up until 2hrs before procedure. Drink 240mL orally every 10 mins or 20–30mL/min by NG tube until rectal effluent is clear or 1 gallon consumed. May interrupt if severe GI disturbances occur.
Children
Not established.
Golytely Contraindications
Contraindications
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.
Golytely Boxed Warnings
Not Applicable
Golytely Warnings/Precautions
Warnings/Precautions
Not for direct ingestion. Correct fluid/electrolyte abnormalities prior to initiation. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment: monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Semi- or unconscious patients. Risk for regurgitation or aspiration. Maintain adequate hydration. Pregnancy. Nursing mothers.
Golytely Pharmacokinetics
See Literature
Golytely Interactions
Interactions
Avoid concomitant with starch-based thickeners. Caution with drugs that increase risk of fluid/electrolyte abnormalities, arrhythmias or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate). Oral drugs administered within 1hr of start of Golytely may not be absorbed.
Golytely Adverse Reactions
Adverse Reactions
Nausea, abdominal fullness, bloating, cramps, vomiting, anal irritation; seizures, arrhythmias, mucosal ulcerations and ischemic colitis, hypersensitivity reactions.
Golytely Clinical Trials
See Literature
Golytely Note
Not Applicable
Golytely Patient Counseling
See Literature
