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Famotidine Injection Preservative-free Generic Name & Formulations
Legal Class
Rx
General Description
Famotidine 20mg/50mL; soln for IV infusion; preservative-free.
Pharmacological Class
H2 blocker.
How Supplied
Tabs—30, 100; Susp—50mL; Inj—contact supplier
Manufacturer
Famotidine Injection Preservative-free Indications
Indications
Hospitalized patients with pathological hypersecretory conditions, intractable ulcers, or as a short-term alternative to oral dosage forms.
Famotidine Injection Preservative-free Dosage and Administration
Adult
Give by IV inj over 2 mins or infuse over 15–30 mins. 20mg every 12hrs.
Children
See full labeling. Give by IV inj over 2 mins or infuse over 15 mins. <1yr: not recommended. 1–16yrs: initially 0.25mg/kg every 12hrs; max 40mg/day.
Famotidine Injection Preservative-free Contraindications
Contraindications
History of serious hypersensitivity reactions to H2 receptor antagonists.
Famotidine Injection Preservative-free Boxed Warnings
Not Applicable
Famotidine Injection Preservative-free Warnings/Precautions
Warnings/Precautions
Symptomatic response does not preclude gastric malignancy; evaluate prior to initiation. Moderate to severe renal impairment (CrCl <50mL/min): reduce to ½ the dose or prolong dosing interval to 36–48hrs. Elderly: use low doses. Pregnancy. Nursing mothers.
Famotidine Injection Preservative-free Pharmacokinetics
See Literature
Famotidine Injection Preservative-free Interactions
Interactions
Concomitant dasatinib, delavirdine mesylate, cefditoren, fosamprenavir: not recommended. May alter absorption of pH-dependent drugs (eg, atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, rilpivirine). May potentiate CYP1A2 substrates (eg, tizanidine); avoid; if necessary, monitor for hypotension, bradycardia, drowsiness. May give antacids concomitantly.
Famotidine Injection Preservative-free Adverse Reactions
Adverse Reactions
Headache, dizziness, constipation, diarrhea, inj site reactions; rare: CNS reactions, prolonged QT interval in renal impairment (moderate and severe).
Famotidine Injection Preservative-free Clinical Trials
See Literature
Famotidine Injection Preservative-free Note
Not Applicable
Famotidine Injection Preservative-free Patient Counseling
See Literature
