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Famotidine Injection Generic Name & Formulations
Legal Class
Rx
General Description
Famotidine 10mg/mL; soln for IV inj or infusion after dilution; multidose vials contain benzyl alcohol.
Pharmacological Class
H2 blocker.
How Supplied
Tabs—30, 100; Susp—50mL; Inj—contact supplier
Manufacturer
Famotidine Injection Indications
Indications
Hospitalized patients with pathological hypersecretory conditions, intractable ulcers, or as a short-term alternative to oral dosage forms.
Famotidine Injection Dosage and Administration
Adult
Give by IV inj over 2 mins or infuse over 15–30 mins. 20mg every 12hrs.
Children
See full labeling. Give by IV inj over 2 mins or infuse over 15 mins. <1yr: not recommended. 1–16yrs: initially 0.25mg/kg every 12hrs; max 40mg/day.
Famotidine Injection Contraindications
Contraindications
History of serious hypersensitivity reactions to H2 receptor antagonists.
Famotidine Injection Boxed Warnings
Not Applicable
Famotidine Injection Warnings/Precautions
Warnings/Precautions
Symptomatic response does not preclude gastric malignancy; evaluate prior to initiation. Moderate to severe renal impairment (CrCl <50mL/min): reduce to ½ the dose or prolong dosing interval to 36–48hrs. Elderly: use low doses. Pregnancy. Nursing mothers.
Famotidine Injection Pharmacokinetics
See Literature
Famotidine Injection Interactions
Interactions
Concomitant dasatinib, delavirdine mesylate, cefditoren, fosamprenavir: not recommended. May alter absorption of pH-dependent drugs (eg, atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, rilpivirine). May potentiate CYP1A2 substrates (eg, tizanidine); avoid; if necessary, monitor for hypotension, bradycardia, drowsiness. May give antacids concomitantly.
Famotidine Injection Adverse Reactions
Adverse Reactions
Headache, dizziness, constipation, diarrhea, inj site reactions; rare: CNS reactions, prolonged QT interval in renal impairment (moderate and severe).
Famotidine Injection Clinical Trials
See Literature
Famotidine Injection Note
Notes
Formerly known under the brand name Pepcid Injection.
Famotidine Injection Patient Counseling
See Literature
