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Droperidol Generic Name & Formulations
Legal Class
Rx
General Description
Droperidol 2.5mg/mL; soln for IV or IM inj.
Pharmacological Class
Neuroleptic.
How Supplied
Contact supplier.
Manufacturer
Droperidol Indications
Indications
To reduce incidence of nausea and vomiting associated with surgical and diagnostic procedures.
Droperidol Dosage and Administration
Adult
Max initial dose: 2.5mg IM or slow IV; may give additional 1.25mg doses to achieve desired effect.
Children
<2yrs: not recommended. ≥2yrs: max initial dose: 0.1mg/kg.
Droperidol Contraindications
Contraindications
QT prolongation (including congenital long QT syndrome).
Droperidol Boxed Warnings
Not Applicable
Droperidol Warnings/Precautions
Warnings/Precautions
Perform ECG prior to administration to determine if prolonged QT interval present; if prolonged, do not administer unless treatment outweighs risks; if treating, monitor for arrhythmias: perform ECG prior to treatment and 2–3hrs after completion. Risk factors for QT prolongation: CHF, bradycardia, cardiac hypertrophy, hypokalemia, hypomagnesemia, >65yrs, alcohol abuse. Pheochromocytoma. Hepatic or renal impairment. Elderly. Debilitated. Critically ill. Labor & delivery: not recommended. Pregnancy (Cat.C). Nursing mothers.
Droperidol Pharmacokinetics
See Literature
Droperidol Interactions
Interactions
Risk of QT prolongation with concomitant Class I and III antiarrhythmics, MAOIs, antimalarials, calcium channel blockers, benzodiazepines, volatile anesthetics, IV opiates, other drugs that prolong QT interval. Caution with drugs that induce hypokalemia, hypomagnesemia (eg, diuretics, laxatives). Additive effects with CNS depressants (eg, barbiturates, tranquilizers, opioids, general anesthetics). Possible hypertension with concomitant fentanyl citrate inj.
Droperidol Adverse Reactions
Adverse Reactions
Hypotension, tachycardia, dysphoria, drowsiness, restlessness, hyperactivity, anxiety, QT prolonation, torsade de pointes, cardiac arrest, ventricular tachycardia, neuroleptic malignant syndrome, post-op hallucinatory episodes.
Droperidol Clinical Trials
See Literature
Droperidol Note
Notes
Formerly known under the brand name Inapsine.
Droperidol Patient Counseling
See Literature
