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Dicyclomine Generic Name & Formulations
Legal Class
Rx
General Description
Dicyclomine HCl 10mg caps; 20mg tabs.
Pharmacological Class
Anticholinergic.
How Supplied
Caps, tabs, syrup—contact supplier; Amps (2mL)—5
Manufacturer
Dicyclomine Indications
Indications
Irritable bowel syndrome.
Dicyclomine Dosage and Administration
Adult
Initially 20mg 4 times daily; after 1 week may increase to 40mg 4 times daily if tolerated. Discontinue if not effective within 2 weeks or daily doses ≥80mg are not tolerated.
Children
<6mos: see Contraindications. ≥6mos: consult manufacturer.
Dicyclomine Contraindications
Contraindications
Glaucoma. Unstable cardiovascular status. GI or urinary tract obstruction. Severe ulcerative colitis. Myasthenia gravis. Reflux esophagitis. Children <6months of age. Nursing mothers.
Dicyclomine Boxed Warnings
Not Applicable
Dicyclomine Warnings/Precautions
Warnings/Precautions
Inj: avoid IV administration (may cause thrombosis, inj site reactions). Autonomic neuropathy. Hepatic or renal impairment. Cardiovascular disease. Hypertension. Hyperthyroidism. Salmonella dysentery. Toxic megacolon. Ulcerative colitis. GI or GU obstruction. High environmental temperature. Diarrhea. Elderly. Debilitated. Pregnancy (Cat.B).
Dicyclomine Pharmacokinetics
See Literature
Dicyclomine Interactions
Interactions
Antacids may inhibit absorption; avoid. May antagonize anti-glaucoma agents or drugs that alter GI motility (eg, metoclopramide). Antagonized by agents used to treat achlorhydria and those used to test gastric secretion. Additive anticholinergic effects with other anticholinergics, narcotic analgesics, type I antiarrhythmics, antihistamines, antipsychotics, tricyclics, amantadine, benzodiazepines, MAOIs, nitrites, nitrates, sympathomimetics. May affect absorption of sust rel dosage forms.
Dicyclomine Adverse Reactions
Adverse Reactions
Dizziness, dry mouth, blurred vision, nausea, somnolence, asthenia, and nervousness; cardiovascular and CNS symptoms (eg, psychosis, delirium). Fatal reactions have occurred in infants.
Dicyclomine Clinical Trials
See Literature
Dicyclomine Note
Notes
Formerly known under the brand name Bentyl.
Dicyclomine Patient Counseling
See Literature
