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Diclegis Generic Name & Formulations
Legal Class
Rx
General Description
Doxylamine succinate 10mg, pyridoxine HCl 10mg; del-rel tabs.
Pharmacological Class
Antihistamine + Vit. B6 analog.
How Supplied
Tabs—100
Manufacturer
Generic Availability
NO
Diclegis Indications
Indications
Nausea and vomiting of pregnancy in women who do not respond to conservative management.
Limitations of Use
Not studied in women with hyperemesis gravidarum.
Diclegis Dosage and Administration
Adult
Swallow whole. Take on empty stomach with water. ≥18yrs: Day 1: initially 2 tabs at bedtime; continue same dose next day if symptoms adequately controlled. If symptoms persist into afternoon of Day 2, take usual dose of 2 tabs at bedtime that night, and then starting on Day 3 take 3 tabs (1 tablet in AM and 2 tabs at bedtime); continue if symptoms adequately controlled. If symptoms persist, starting on Day 4 take 4 tabs (1 tab in the AM, 1 tab mid-afternoon, and 2 tabs at bedtime). Max 4 tabs daily.
Children
<18yrs: not established.
Diclegis Contraindications
Contraindications
Concomitant MAOIs; may prolong and intensify anticholinergic effects.
Diclegis Boxed Warnings
Not Applicable
Diclegis Warnings/Precautions
Warnings/Precautions
Asthma. Increased intraocular pressure. Narrow angle glaucoma. Stenosing peptic ulcer. Pyloroduodenal obstruction. Urinary bladder-neck obstruction. Reevaluate as pregnancy progresses. Nursing mothers: not recommended.
Diclegis Pharmacokinetics
See Literature
Diclegis Interactions
Interactions
See Contraindications. Concomitant alcohol, other CNS depressants (eg, hypnotic sedatives, tranquilizers): not recommended. Concomitant food may delay onset of action and reduce absorption. May cause false (+) urine test for methadone, opiates, PCP.
Diclegis Adverse Reactions
Adverse Reactions
Somnolence.
Diclegis Clinical Trials
See Literature
Diclegis Note
Not Applicable
Diclegis Patient Counseling
See Literature
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