Creon

See literature. Start at the lowest recommended dose and increase gradually. Individualize based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Infants: May sprinkle directly into mouth or into a small amount of applesauce; do not mix directly into formula or breastmilk. ≤12months: 3000 lipase units per 120mL of formula or per breastfeeding. Children and adults: Do not crush or chew caps; swallow whole, or may open and sprinkle contents into small amount of acidic food (pH≤4) and swallow mixture immediately. >12months–<4yrs: 1000 lipase units/kg per meal; ≥4yrs: 500 lipase units/kg per meal. Max (for children and adults): 2500 lipase units/kg per meal (or ≤10000 lipase units/kg per day), or <4000 lipase units/g fat ingested per day. Adults with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatectomy: individualize; in one study, patients received 72,000 lipase units per meal while consuming 100g of fat per day; lower starting doses are consistent with the 500 lipase units/kg per meal lowest starting dose recommended for adults in the guidelines.