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Cimetidine Generic Name & Formulations
Legal Class
Rx
General Description
Cimetidine 200mg, 300mg, 400mg, 800mg; tabs.
Pharmacological Class
H2 blocker.
How Supplied
Contact supplier
Manufacturer
Cimetidine Indications
Indications
Active duodenal or benign gastric ulcer. Maintenance of healed duodenal ulcers. Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome). GERD.
Cimetidine Dosage and Administration
Adult
Active duodenal ulcer: 800mg at bedtime for 4–8 weeks. Maintenance: 400mg at bedtime. Active benign gastric ulcer: 800mg at bedtime or 300mg 4 times daily with meals and at bedtime for 6 weeks. Hypersecretory conditions: 300mg 4 times daily with meals and at bedtime; max 2.4g/day. GERD: 800mg 2 times daily or 400mg 4 times daily for max 12 weeks; see full labeling. For difficult to heal ulcers: see full labeling.
Children
<16yrs: not recommended; see full labeling. Doses of 20–40mg/kg per day have been used.
Cimetidine Contraindications
Not Applicable
Cimetidine Boxed Warnings
Not Applicable
Cimetidine Warnings/Precautions
Warnings/Precautions
Impaired renal or hepatic function. Elderly. Debilitated. Immunocompromised. Pregnancy (Cat.B). Nursing mothers: not recommended.
Cimetidine Pharmacokinetics
See Literature
Cimetidine Interactions
Interactions
Avoid antacids within 1 hour of dosing. May potentiate anticoagulants, phenytoin, theophylline, lidocaine, and others (see literature) by inhibition of hepatic microsomal enzymes. May alter absorption of drugs affected by gastric pH (e.g., ketoconazole), give 2 hours before cimetidine.
Cimetidine Adverse Reactions
Adverse Reactions
Headache, diarrhea, dizziness, somnolence, CNS disturbances, gynecomastia, rash (maybe serious eg, Stevens-Johnson syndrome); rare: arthralgia, myalgia, blood dyscrasias, nephritis, increased serum transaminases, pancreatitis, bradycardia, tachycardia; increased risk of community-acquired pneumonia (see literature).
Cimetidine Clinical Trials
See Literature
Cimetidine Note
Notes
Formerly known under the brand name Tagamet.
Cimetidine Patient Counseling
See Literature
