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Chlorpromazine Injection Generic Name & Formulations
Legal Class
Rx
General Description
Chlorpromazine HCl 25mg/mL; for IV inj after dilution or IM inj; contains sulfites; multidose vials contain benzyl alcohol.
Pharmacological Class
Phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Chlorpromazine Injection Indications
Indications
Nausea and vomiting.
Chlorpromazine Injection Dosage and Administration
Adult
25–50mg IM every 3–4hrs if needed.
Children
<6months: not recommended. ≥6months: 0.25mg/lb IM every 6–8hrs if needed. <5yrs or <50lbs: max 40mg/day; ≥5yrs or 50–100lbs: usual max 75mg/day.
Chlorpromazine Injection Contraindications
Contraindications
Coma. CNS or bone marrow depression. Reye's syndrome.
Chlorpromazine Injection Boxed Warnings
Not Applicable
Chlorpromazine Injection Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.
Chlorpromazine Injection Pharmacokinetics
See Literature
Chlorpromazine Injection Interactions
Interactions
Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.
Chlorpromazine Injection Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.
Chlorpromazine Injection Clinical Trials
See Literature
Chlorpromazine Injection Note
Notes
Formerly known under the brand name Thorazine.
Chlorpromazine Injection Patient Counseling
See Literature
Chlorpromazine Injection Generic Name & Formulations
Legal Class
Rx
General Description
Chlorpromazine HCl 25mg/mL; for IV inj after dilution or IM inj; contains sulfites; multidose vials contain benzyl alcohol.
Pharmacological Class
Aliphatic phenothiazine.
See Also
How Supplied
Contact supplier.
Manufacturer
Chlorpromazine Injection Indications
Indications
Rapid control of severe psychotic symptoms. Severe childhood behavior disorders. Adjunct in tetanus.
Chlorpromazine Injection Dosage and Administration
Adult
Psychosis: 25mg IM; may repeat in 1 hour, then switch to oral forms. Tetanus: 25–50mg IM 3–4 times daily or 25–50mg IV (see literature).
Children
<6months: not recommended. ≥6months: Severe behavior disorders: 0.25mg/lb IM every 6–8 hrs if needed. Tetanus: 0.25mg/lb IM or IV (see literature) every 6–8 hrs. Both: <5yrs or <50lbs: max 40mg/day; ≥5yrs or 50–100lbs: usual max 75mg/day.
Chlorpromazine Injection Contraindications
Contraindications
Coma. CNS or bone marrow depression. Reye's syndrome.
Chlorpromazine Injection Boxed Warnings
Not Applicable
Chlorpromazine Injection Warnings/Precautions
Warnings/Precautions
Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.
Chlorpromazine Injection Pharmacokinetics
See Literature
Chlorpromazine Injection Interactions
Interactions
Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.
Chlorpromazine Injection Adverse Reactions
Adverse Reactions
Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.
Chlorpromazine Injection Clinical Trials
See Literature
Chlorpromazine Injection Note
Notes
Formerly known under the brand name Thorazine.
Chlorpromazine Injection Patient Counseling
See Literature
