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Cesamet Generic Name & Formulations
Legal Class
CII
General Description
Nabilone 1mg; caps.
Pharmacological Class
Cannabinoid.
How Supplied
Caps—20
Manufacturer
Cesamet Indications
Indications
Treatment of nausea and vomiting associated with cancer chemotherapy in patients who have not responded adequately to other antiemetics.
Cesamet Dosage and Administration
Adult
1–2mg twice daily; max 6mg/day in 3 divided doses. Give 1st dose 1–3 hours before chemotherapy is administered; use lower starting dose and increase if necessary. May give 1–2mg the night before chemo. Continue 2–3 doses/day during chemotherapy course, if needed, may continue 48 hours after each chemo cycle.
Children
<18yrs: not recommended.
Cesamet Contraindications
Not Applicable
Cesamet Boxed Warnings
Not Applicable
Cesamet Warnings/Precautions
Warnings/Precautions
Hypertension. Heart disease. History of psychiatric disorders (eg, bipolar disorder, depression, schizophrenia) or substance abuse. Write ℞ for limited quantity (ie, enough for one chemotherapy course). Keep patient under responsible adult supervision (esp. when dose is adjusted). Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Cesamet Pharmacokinetics
See Literature
Cesamet Interactions
Interactions
Potentiates CNS depression with benzodiazepines, barbiturates, alcohol, other CNS depressants and other psychoactive substances (avoid). May affect, or be affected by, other drugs that undergo first-pass hepatic metabolism or that are highly protein bound (eg, sympathomimetics, anticholinergics, tricyclic antidepressants). Cross-tolerance and mutual potentiation with opioids. Naltrexone: see literature.
Cesamet Adverse Reactions
Adverse Reactions
Drowsiness, vertigo, dry mouth, euphoria/dysphoria, ataxia, headache, tachycardia, hypotension, concentration difficulties, sleep disturbance, other psychiatric reactions (may persist for several days after dosing), changes in appetite.
Cesamet Clinical Trials
See Literature
Cesamet Note
Not Applicable
Cesamet Patient Counseling
See Literature
