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Akynzeo For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Fosnetupitant, palonosetron; 235mg/0.25mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.
Pharmacological Class
Substance P/NK1 receptor antagonist + 5-HT3 receptor antagonist.
See Also
How Supplied
Tabs—1, 4; Single-dose vials (pwd or soln)—1
Manufacturer
Generic Availability
NO
Akynzeo For Injection Indications
Indications
Prevention of acute and delayed nausea and vomiting due to initial and repeat courses of highly emetogenic chemotherapy.
Limitations of Use
Not studied for prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.
Akynzeo For Injection Dosage and Administration
Adult
Infuse over 30mins. ≥18yrs: Highly emetogenic chemotherapy (including cisplatin-based): 1 vial approx. 30mins prior to chemotherapy with oral dexamethasone 12mg given 30mins before chemotherapy on Day 1, then 8mg orally once daily on Days 2–4.
Children
<18yrs: not established.
Akynzeo For Injection Contraindications
Not Applicable
Akynzeo For Injection Boxed Warnings
Not Applicable
Akynzeo For Injection Warnings/Precautions
Warnings/Precautions
Monitor for symptoms of serotonin syndrome; discontinue and treat if occurs. Severe hepatic or renal impairment, ESRD: avoid. Elderly. Pregnancy. Nursing mothers.
Akynzeo For Injection Pharmacokinetics
See Literature
Akynzeo For Injection Interactions
Interactions
Increased risk of serotonin syndrome with concomitant other serotonergic drugs (eg, SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue). May potentiate CYP3A4 substrates (eg, dexamethasone [use reduced dose], midazolam, alprazolam, triazolam, docetaxel, paclitaxel, etoposide, irinotecan, cyclophosphamide, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine); caution and monitor. Avoid concomitant strong CYP3A4 inducers (eg, rifampin). Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). Concomitant warfarin: monitor INR and adjust dose as needed. Inj: incompatible with divalent cation-containing solutions, Lactated Ringer's Injection, Hartmann's Solution.
Akynzeo For Injection Adverse Reactions
Adverse Reactions
Headache, asthenia, dyspepsia, fatigue, constipation, erythema; hypersensitivity reactions.
Akynzeo For Injection Clinical Trials
See Literature
Akynzeo For Injection Note
Not Applicable
Akynzeo For Injection Patient Counseling
See Literature
