Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Akynzeo Generic Name & Formulations
Legal Class
Rx
General Description
Netupitant, palonosetron (as HCl); 300mg/0.5mg; hard gel caps.
Pharmacological Class
Substance P/NK1 receptor antagonist + 5-HT3 receptor antagonist.
How Supplied
Tabs—1, 4; Single-dose vials (pwd or soln)—1
Manufacturer
Generic Availability
NO
Akynzeo Indications
Indications
Prevention of acute and delayed nausea and vomiting due to initial and repeat courses of chemotherapy, including highly emetogenic chemotherapy.
Akynzeo Dosage and Administration
Adult
≥18yrs: Highly emetogenic chemotherapy (including cisplatin-based): 1 cap approx. 1hr prior to chemotherapy with oral dexamethasone 12mg given 30mins before chemotherapy on Day 1, then 8mg orally once daily on Days 2–4. Anthracyclines and cyclophosphamide-based chemotherapy, or non-highly emetogenic chemotherapy: 1 cap approx. 1hr prior to chemotherapy with oral dexamethasone 12mg given 30mins prior to chemotherapy on Day 1.
Children
<18yrs: not established.
Akynzeo Contraindications
Not Applicable
Akynzeo Boxed Warnings
Not Applicable
Akynzeo Warnings/Precautions
Warnings/Precautions
Monitor for symptoms of serotonin syndrome; discontinue and treat if occurs. Severe hepatic or renal impairment, ESRD: avoid. Elderly. Pregnancy. Nursing mothers.
Akynzeo Pharmacokinetics
See Literature
Akynzeo Interactions
Interactions
Increased risk of serotonin syndrome with concomitant other serotonergic drugs (eg, SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue). May potentiate CYP3A4 substrates (eg, dexamethasone [use reduced dose], midazolam, alprazolam, triazolam, docetaxel, paclitaxel, etoposide, irinotecan, cyclophosphamide, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine); caution and monitor. Avoid concomitant strong CYP3A4 inducers (eg, rifampin). Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). Concomitant warfarin: monitor INR and adjust dose as needed. Inj: incompatible with divalent cation-containing solutions, Lactated Ringer's Injection, Hartmann's Solution.
Akynzeo Adverse Reactions
Adverse Reactions
Headache, asthenia, dyspepsia, fatigue, constipation, erythema; hypersensitivity reactions.
Akynzeo Clinical Trials
See Literature
Akynzeo Note
Not Applicable
Akynzeo Patient Counseling
See Literature
Images
